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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionINVOLVED IN TRANSPORT OF AMINOGLYCOSIDES AND TETRACYCLINE ACROSS THE MEMBRANE (EXPORT): DRUG RESISTANCE BY AN EXPORT MECHANISM (CONFERES RESISTANCE TO TOXIC COMPOUNDS BY REMOVING THEM FOR THE CELLS). RESPONSIBLE FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE.
ProductAminoglycoside/tetracycline-transport integral membrane protein
CommentsML0556c, len: 509 aa. Aminoglycoside/tetracycline-transport integral membrane protein (see citation below), member of major facilitator superfamily (MFS), highly similar to P71678|AL123456|Rv1410c Aminoglycoside/tetracycline-transport integral membrane protein from M. tuberculosis (518 aa), Fasta scores: E(): 0, (82.0% identity in 506 aa overlap); and CAD94306|Mb1445c from M. bovis (518 aa). Similar to others e.g. P96712|D50098 bmr3, multidrug transporter from Bacillus subtilis (512 aa), Fasta scores: E(): 5.4e-24, (27.1% identity in 446 aa overlap). Also similar to ML1562. Contains hydrophobic, probable membrane-spanning regions. Contains Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter. Contains PS00216 Sugar transport proteins signature 1. Note that the ML0556c-ML0557c operon seems transcribed from two promoters in Mycobacterium bovis BCG (see Bigi et al., 2000)
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS673151674680-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML0556c|ML0556c
MSTRAGRRVAISAGSLAVLLGALDTYVVVTIMRDIMHDVGIPVNQMQRITWIVTMYLLGYIAAMPLLSRASDRFGRKLLLQVSLAGFAIGSVMTALAGQFGDFHMLIAGRTIQGVASGALLPITLALGADLWAQRNRAGVLGGIGAAQELGSVLGPLYGIFIVWLFSDWRYVFWINIPLTAIAMLMIQVSLSAHDRGDELEKVDVVGGVLLAIALGLVVIGLYNPQPDSKQVLPSYGVPVLVGGIVATVAFAVWERCARTRLIDPAGVHIRPFLSALGASVAAGAALMVTLVNVELFGQGVLGMDQTQAAGLLVWFLIALPIGAVLGGWGATKAGDRTMTFVGLLITAGGYWLISHWPVDLLNYRRSIFGLFSVPTMYADLLVAGLGLGLVIGPLSSATLRVVPTAQHGIASAAVVVARMTGMLIGVAALTAWGLYRFNQILAGLSTAVPPDATLIERAAAVADQAKRAYTMMYSDIFMITAIVCVIGALLGLLISSRKEHASEPKVPE
      
Bibliography
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