Gene ML0556c (P55)
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN TRANSPORT OF AMINOGLYCOSIDES AND TETRACYCLINE ACROSS THE MEMBRANE (EXPORT): DRUG RESISTANCE BY AN EXPORT MECHANISM (CONFERES RESISTANCE TO TOXIC COMPOUNDS BY REMOVING THEM FOR THE CELLS). RESPONSIBLE FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE. |
| Product | Aminoglycoside/tetracycline-transport integral membrane protein |
| Comments | ML0556c, len: 509 aa. Aminoglycoside/tetracycline-transport integral membrane protein (see citation below), member of major facilitator superfamily (MFS), highly similar to P71678|AL123456|Rv1410c Aminoglycoside/tetracycline-transport integral membrane protein from M. tuberculosis (518 aa), Fasta scores: E(): 0, (82.0% identity in 506 aa overlap); and CAD94306|Mb1445c from M. bovis (518 aa). Similar to others e.g. P96712|D50098 bmr3, multidrug transporter from Bacillus subtilis (512 aa), Fasta scores: E(): 5.4e-24, (27.1% identity in 446 aa overlap). Also similar to ML1562. Contains hydrophobic, probable membrane-spanning regions. Contains Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter. Contains PS00216 Sugar transport proteins signature 1. Note that the ML0556c-ML0557c operon seems transcribed from two promoters in Mycobacterium bovis BCG (see Bigi et al., 2000) |
| Functional category | Cell wall and cell processes |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 673151 | 674680 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0556c|ML0556c
MSTRAGRRVAISAGSLAVLLGALDTYVVVTIMRDIMHDVGIPVNQMQRITWIVTMYLLGYIAAMPLLSRASDRFGRKLLLQVSLAGFAIGSVMTALAGQFGDFHMLIAGRTIQGVASGALLPITLALGADLWAQRNRAGVLGGIGAAQELGSVLGPLYGIFIVWLFSDWRYVFWINIPLTAIAMLMIQVSLSAHDRGDELEKVDVVGGVLLAIALGLVVIGLYNPQPDSKQVLPSYGVPVLVGGIVATVAFAVWERCARTRLIDPAGVHIRPFLSALGASVAAGAALMVTLVNVELFGQGVLGMDQTQAAGLLVWFLIALPIGAVLGGWGATKAGDRTMTFVGLLITAGGYWLISHWPVDLLNYRRSIFGLFSVPTMYADLLVAGLGLGLVIGPLSSATLRVVPTAQHGIASAAVVVARMTGMLIGVAALTAWGLYRFNQILAGLSTAVPPDATLIERAAAVADQAKRAYTMMYSDIFMITAIVCVIGALLGLLISSRKEHASEPKVPE
Bibliography
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