Gene ML0558
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN RIBOFLAVIN SYNTHESIS. RIBOFLAVIN SYNTHASE IS A BIFUNCTIONAL ENZYME COMPLEX CATALYZING THE FORMATION OF RIBOFLAVIN FROM 5-AMINO-6-(1'-D)- RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE AND L-3,4-DIHYDROHY-2- BUTANONE-4-PHOSPHATE VIA 6,7-DIMETHYL-8-LUMAZINE. THE ALPHA SUBUNIT CATALYZES THE DISMUTATION OF 6,7-DIMETHYL-8-LUMAZINE TO RIBOFLAVIN AND 5-AMINO-6-(1'-D)-RIBITYL-AMINO-2,4(1H,3H)- PYRIMIDINEDIONE. |
| Product | Probable riboflavin synthase [alpha] chain RibC (RibE) |
| Comments | ML0558, len: 207 aa. Probable ribC (ribE), Riboflavin synthase alpha chain (EC 2.5.1.9), highly similar to RISA_MYCTU|P71680|Rv1412 ribC, riboflavin synthase [alpha] chain from M. tuberculosis (201 aa), Fasta scores: E(): 7.1e-66, (82.4% identity in 199 aa overlap); and CAD94308|Mb1447 from M. bovis (201 aa). Similar to many e.g. RISA_BACSU|P16440 ribE, riboflavin synthase alpha chain from Bacillus subtilis (215 aa), Fasta scores: E(): 9.5e-28, (43.4% identity in 198 aa overlap). Contains 2 Pfam matches to entry PF00677 Lum_binding, Lumazine binding domain. Contains 2 x PS00693 Riboflavin synthase alpha chain family signature. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 675553 | 676176 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0558|ribC
MFTGIVEELGEVVGRDAHADAARLIIRGRTVTADAGHGDSIAVNGVCLTVVEVLPDGQFSADVMAETLHRSNLGELRVGNRVNLERAVAINSRLGGHIVQGHVDGTGEVVARTLSDHWEVVRIEVPPAVARYFVEKGSITVDGISLTVSGLGAEPRDWLEVSLIPTTRELTTLGRTPLGTQVNLEVDVIAKYVERLLQSVPTGDLTR
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