Gene ML0559 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameribA
Gene length1308 bp
IdentifierML0559
Location 676303 bp
Protein summary information
Molecular mass47009.2 Da
Isoelectric point5.61
Protein length436 amino acids
Structural information
PFAMPF00925, PF00926
Orthologues
M. tuberculosisRv1415
Cross-references
UniProtQ9CCP4
Gene OntologyGtp cyclohydrolase ii activity, Metal ion binding, Riboflavin biosynthetic process, 3,4-dihydroxy-2-butanone-4-phosphate synthase activity
Enzyme Classification3.5.4.25
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable riboflavin biosynthesis protein RibA : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase)
CommentsML0559, len: 435 aa. Probable ribA, Riboflavin biosynthesis protein (EC 3.5.4.25), highly similar to GCH2_MYCTU|P71684|Rv1415 ribA2, probable Riboflavin biosynthesis protein from M. tuberculosis (425 aa), Fasta scores: E(): 1.1e-171, (93.4% identity in 425 aa overlap); and CAD94311|Mb1450 from M. bovis (425 aa). Similar to many e.g. O24752|GCH2_CORAM Riboflavin biosynthesis protein ribA from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (423 aa), fasta scores: E(): 3.2e-105, (60.775% identity in 413 aa overlap). Contains Pfam match to entry PF00926 DHBP_synthase, 3,4-dihydroxy-2-butanone 4-phosphate synthase. Contains Pfam match to entry PF00925 GTP_cyclohydro2, GTP cyclohydrolase II. IN THE N-TERMINAL SECTION; BELONGS TO THE DHBP SYNTHASE FAMILY. IN THE C-TERMINAL SECTION; BELONGS TO THE GTP CYCLOHYDROLASE II FAMILY.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS676303677610+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0559|ribA
VGPFDSKVAKMTRLDSVERAVADIAAGKAVVVIDDEDRENEGDLIFAAEKATLEMVAFMVRYTSGYLCAPLDGAICDRLGLLPMFAVNQDKHGTAYTVTVDARNGVGTGISASDRATTMRLLADPASVADDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARLAGLQPAGAICEIVSQKDEGSMAQTDELRVFADEHDLALITIADLIAWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYDDVKHVALVRGEIAGSSGDGDDILVRVHSECLTGDVFGSRRCDCGTQLDAAMAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADTVDANIKLGFPSDARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLQIIERVPLPVRANADNIRYLMTKRDKMGHDLGGLDDFHESNYFPGEFGGAL
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