Gene ML0559
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable riboflavin biosynthesis protein RibA : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) |
| Comments | ML0559, len: 435 aa. Probable ribA, Riboflavin biosynthesis protein (EC 3.5.4.25), highly similar to GCH2_MYCTU|P71684|Rv1415 ribA2, probable Riboflavin biosynthesis protein from M. tuberculosis (425 aa), Fasta scores: E(): 1.1e-171, (93.4% identity in 425 aa overlap); and CAD94311|Mb1450 from M. bovis (425 aa). Similar to many e.g. O24752|GCH2_CORAM Riboflavin biosynthesis protein ribA from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (423 aa), fasta scores: E(): 3.2e-105, (60.775% identity in 413 aa overlap). Contains Pfam match to entry PF00926 DHBP_synthase, 3,4-dihydroxy-2-butanone 4-phosphate synthase. Contains Pfam match to entry PF00925 GTP_cyclohydro2, GTP cyclohydrolase II. IN THE N-TERMINAL SECTION; BELONGS TO THE DHBP SYNTHASE FAMILY. IN THE C-TERMINAL SECTION; BELONGS TO THE GTP CYCLOHYDROLASE II FAMILY. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 676303 | 677610 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0559|ribA
VGPFDSKVAKMTRLDSVERAVADIAAGKAVVVIDDEDRENEGDLIFAAEKATLEMVAFMVRYTSGYLCAPLDGAICDRLGLLPMFAVNQDKHGTAYTVTVDARNGVGTGISASDRATTMRLLADPASVADDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARLAGLQPAGAICEIVSQKDEGSMAQTDELRVFADEHDLALITIADLIAWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYDDVKHVALVRGEIAGSSGDGDDILVRVHSECLTGDVFGSRRCDCGTQLDAAMAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADTVDANIKLGFPSDARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLQIIERVPLPVRANADNIRYLMTKRDKMGHDLGGLDDFHESNYFPGEFGGAL
Bibliography
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