Gene ML0560
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | RIBOFLAVIN SYNTHASE IS A BIFUNCTIONAL ENZYME COMPLEX INVOLVED IN RIBOFLAVIN SYNTHESIS. RIBOFLAVIN SYNTHASE CATALYZES THE FORMATION OF RIBOFLAVIN FROM 5-AMINO-6-(1'-D)- RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE AND L-3,4-DIHYDROHY-2- BUTANONE-4-PHOSPHATE VIA 6,7-DIMETHYL-8-LUMAZINE. THE BETA SUBUNIT CATALYZES THE CONDENSATION OF 5-AMINO-6-(1'-D)-RIBITYL- AMINO-2,4(1H,3H)-PYRIMIDINEDIONE WITH L-3,4-DIHYDROHY-2-BUTANONE- 4-PHOSPHATE YIELDING 6,7-DIMETHYL-8-LUMAZINE. |
| Product | Probable riboflavin synthase beta chain RibH (6,7-dimethyl-8-ribityllumazine synthase) (DMRL synthase) (Lumazine synthase). |
| Comments | ML0560, len: 160 aa. Probable ribH, riboflavin synthase beta chain (EC 2.5.1.9), highly similar to RISB_MYCTU|P71685|Rv1416 ribH, riboflavin synthase [beta] chain from M. tuberculosis (154 aa), Fasta scores: E(): 0, (78.9% identity in 152 aa overlap); and CAD94312|Mb1451 from M. bovis (154 aa). Similar to many e.g. Q9EWJ9|RISB_STRCO 6,7-dimethyl-8-ribityllumazine synthase from Streptomyces coelicolor (161 aa), fasta scores: E(): 3.8e-30, (54.305% identity in 151 aa overlap). Contains Pfam match to entry PF00885 DMRL_synthase, 6,7-dimethyl-8-ribityllumazine synthase. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 677607 | 678089 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0560|ribH
MSGGAGIPEVPGIDASGLRLGIVASTWHSRICDALLAGARKVAADSGIDGPTVVRVLGAIEIPVVVQELARHHDAVVALGVVIRGDTPHFDYVCNSVTQGLTRIALDTSTPVGNGVLTTNTEKQALDRAGLPTSAEDKGAQAAAAALTTALTLLNLRSRI
Bibliography
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