Gene ML0562
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN NUCLEOTIDE EXCISION REPAIR. THE ABC EXCISION NUCLEASE IS A DNA REPAIR ENZYME THAT CATALYZES THE EXCISION REACTION OF UV-DAMAGED NUCLEOTIDE SEGMENTS PRODUCING OLIGOMERS HAVING THE MODIFIED BASE(S). ATTACHES TO THE UVRA-UVRB COMPLEX, DISPLACING UVRA, AND THE DAMAGED DNA STRAND IS NICKED ON BOTH SIDES OF THE DAMAGED SITE |
| Product | Probable excinuclease ABC (subunit C - nuclease) UvrC (UvrC protein) (Excinuclease ABC subunit C) |
| Comments | ML0562, len: 647 aa. Probable uvrC, excinuclease ABC, subunit C (see citations below), highly similar to UVRC_MYCTU|P71689|Rv1420 uvrC, excinuclease ABC subunit C from M. tuberculosis (646 aa), Fasta scores: E(): 0, (87.6% identity in 646 aa overlap); and CAD94316|1455 from M. bovis (646 aa). Similar to many e.g. Q9Z512|UVRC_STRCO UvrABC system protein C (UvrC protein) from Streptomyces coelicolor (728 aa), fasta scores: E(): 1.4e-90, (57.803% identity in 692 aa overlap). Contains Pfam match to entry PF01541 Exci_endo_N, Endo/excinuclease amino terminal domain. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains Pfam match to entry PF00633 HHH, Helix-hairpin-helix motif. Belongs to the UrvC family. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 678871 | 680814 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0562|uvrC
VPDPATYRPATGSIPVEPGVYRFRDPYGRVIYVGKAKSLRSRLASYFADVANLHPRTRQMVTIAAKVEWTVVNTEVEALQLEYNWIKEFDPRFNIRYRDDKSYPVLAVTLGEEFPRLMVYRGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSPGVFKRHKQIDRPCLLGYIDKCAAPCVGRVGAEQHSQIVADFCDFLSGKTDRYARDLERKMSAAAEQLDFERAARLRDDLFALKRAMEKQAVVFGDGTDADVVAFAYDELEVAVQVFHVRGGRVRGQRGWIVEKSDDPGDTGEEQLVEQFLAQFYGEQAELDFVADESANPVPREVLVPCLPSNADELASWLSGLRGSRVALRVPRRGDKRALAETVQRNAKEELQQHKLKRASDFNSRSAALQNIQDTLGLSYAPLRIECVDISHVQGTDVVGSLVVFEDGLPRKSDYRHFGIRKAAGNGRSDDVASIAEVTRRRFLQHLHDQNDTNLLSPEGKSHRFAYPPNLYVVDGGAPQVNAASTVLEELGIIDVAVIGLAKRLEEVWVPFEPYPVIMPRNSEALFLLQRVRDEAHRFAITYHRSKRSKRMTASALDSVPGLGAHRRKALVTHFGSIARLKDATVEQITAVPGIGVATATAVLEALRPDSSEASE
Bibliography
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