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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionINVOLVED IN NUCLEOTIDE EXCISION REPAIR. THE ABC EXCISION NUCLEASE IS A DNA REPAIR ENZYME THAT CATALYZES THE EXCISION REACTION OF UV-DAMAGED NUCLEOTIDE SEGMENTS PRODUCING OLIGOMERS HAVING THE MODIFIED BASE(S). ATTACHES TO THE UVRA-UVRB COMPLEX, DISPLACING UVRA, AND THE DAMAGED DNA STRAND IS NICKED ON BOTH SIDES OF THE DAMAGED SITE
ProductProbable excinuclease ABC (subunit C - nuclease) UvrC (UvrC protein) (Excinuclease ABC subunit C)
CommentsML0562, len: 647 aa. Probable uvrC, excinuclease ABC, subunit C (see citations below), highly similar to UVRC_MYCTU|P71689|Rv1420 uvrC, excinuclease ABC subunit C from M. tuberculosis (646 aa), Fasta scores: E(): 0, (87.6% identity in 646 aa overlap); and CAD94316|1455 from M. bovis (646 aa). Similar to many e.g. Q9Z512|UVRC_STRCO UvrABC system protein C (UvrC protein) from Streptomyces coelicolor (728 aa), fasta scores: E(): 1.4e-90, (57.803% identity in 692 aa overlap). Contains Pfam match to entry PF01541 Exci_endo_N, Endo/excinuclease amino terminal domain. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains Pfam match to entry PF00633 HHH, Helix-hairpin-helix motif. Belongs to the UrvC family.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS678871680814+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML0562|uvrC
VPDPATYRPATGSIPVEPGVYRFRDPYGRVIYVGKAKSLRSRLASYFADVANLHPRTRQMVTIAAKVEWTVVNTEVEALQLEYNWIKEFDPRFNIRYRDDKSYPVLAVTLGEEFPRLMVYRGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSPGVFKRHKQIDRPCLLGYIDKCAAPCVGRVGAEQHSQIVADFCDFLSGKTDRYARDLERKMSAAAEQLDFERAARLRDDLFALKRAMEKQAVVFGDGTDADVVAFAYDELEVAVQVFHVRGGRVRGQRGWIVEKSDDPGDTGEEQLVEQFLAQFYGEQAELDFVADESANPVPREVLVPCLPSNADELASWLSGLRGSRVALRVPRRGDKRALAETVQRNAKEELQQHKLKRASDFNSRSAALQNIQDTLGLSYAPLRIECVDISHVQGTDVVGSLVVFEDGLPRKSDYRHFGIRKAAGNGRSDDVASIAEVTRRRFLQHLHDQNDTNLLSPEGKSHRFAYPPNLYVVDGGAPQVNAASTVLEELGIIDVAVIGLAKRLEEVWVPFEPYPVIMPRNSEALFLLQRVRDEAHRFAITYHRSKRSKRMTASALDSVPGLGAHRRKALVTHFGSIARLKDATVEQITAVPGIGVATATAVLEALRPDSSEASE
      
Bibliography
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