Gene ML0583c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. It catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor [Catalytic activity: Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate] |
| Product | Probable transketolase Tkt (TK) |
| Comments | ML0583c, len: 699 aa. Probable tkt, Transketolase (EC 2.2.1.1), highly similar to TKT_MYCTU|O06811|Rv1449c tkt, transketolase from M. tuberculosis (700 aa), Fasta scores: E(): 0, (89.1% identity in 700 aa overlap); and CAD96151|Mb1484c from M. bovis (700 aa). Similar to many e.g. TKT2_YEAST|P33315 tkl2, transketolase 2 from Saccharomyces cerevisiae (681 aa), Fasta scores: E(): 3.4e-99, (42.8% identity in 684 aa overlap). Previously sequenced as TKT_MYCLE|P46708 (699 aa), Fasta scores: E(): 0, (99.9% identity in 699 aa overlap). Contains Pfam match to entry PF00456 transketolase, Transketolase. Contains PS00801 Transketolase signature 1. Contains PS00802 Transketolase signature 2. Belongs to the Transketolase family. In M. tuberculosis tkt is thought to be differentially expressed within host cells (see Triccas et al., 1999). |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 707606 | 709705 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0583c|tkt
VTTLDQISTLTQPRHPDDWTEIDSAAVDTIRVLATDAVQKAGNGHPGTAMSLAPLAYTLFQRTLRHDPNDTAWLGRDRFVLSAGHSSLTLYIQLYLGGFGLELSDIESLRTWGSTTPGHPEFRHTKGVEITTGPLGQGLASAVGMAMASRYERGLFDPDAEPGASPFDHYIYVIASDGDIEEGVTSEASSLAAVQQLGNLIVFYDHNQISIEGDTKITLCEDTAARYRAYGWHVQEVEGGENVVGIEEAIANAKAATDRPSFISLRTIIGYPAPTLINTGKAHGAALGEDEVAATKRILGFDPDKTFAVREDVITHTRGLIARGKEAHERWQLEFEAWAQREPERKALLDRLLAQQLPDGWDADLPNWEPRSKELATRAASGAVLSAIGPKLPELWGGSADLAGSNNTTIKDVDSFGPPSISTDEYTAHWYGRTLHFGVREHAMGAILSGIVLHGPTRAYGGTFLQFSDYMRPSVRLASLMDIDTIYVWTHDSVGLGEDGPTHQPIEHLAALRAIPRLSVVRPADANETAYAWRTILARGANSGPVGLILTRQSVPVLEGTNTEGVARGGYVLGDGGSSEAKEPDVILIATGSEVQLAVAAQKLLADKDIIVRVVSMPCVEWFESQPYEYRDSVLPPSVSARVAVEAGVAQCWHKLVGDTGKIVSIEHYGESADYQTLFREYGFTPEAVVAAAEQVLDN
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