Gene ML0611
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable GTP-binding protein LepA |
| Comments | ML0611, len: 646 aa. Probable lepA, GTP-binding protein (a protein of unknown function, but apparently with membrane-related functions and very similar to protein synthesis elongation factors; see citations below). Highly similar to LEPA_MYCTU|P71739|Rv2404c lepA, putative GTP-binding protein from M. tuberculosis (653 aa), Fasta scores: E(): 0, (88.0% identity in 649 aa overlap); and CAD97288|Mb2427c from M. bovis (653 aa). Similar to many e.g. LEPA_BACSU|P37949 lepA, GTP-binding protein from Bacillus subtilis (612 aa), Fasta scores: E(): 5.5e-144, (56.8% identity in 613 aa overlap). Previously sequenced as LEPA_MYCLE|P53530 (646 aa), Fasta scores: E(): 0, (99.8% identity in 646 aa overlap). Show weak similarity to ML1498, ML1877 and ML1878 from M. leprae. Contains Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family. Contains PS00301 GTP-binding elongation factors signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the GTP-binding elongation factor family, LepA subfamily. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 742717 | 744657 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0611|lepA
VSWSLRVDKPDTGESPFKHSLVTGAQEIPISSFADKTFTAPAQIRNFCIIAHIDHGKSTLADRMLQLTGVVDERSMRAQYLDRMDIERERGITIKAQNVRLSWSVTAGGTTENYVLHLIDTPGHVDFTYEVSRALEACEGAVLLVDAVQGIEAQTLANLYLALERDLTIIPVLNKIDLPAADPDRYAAEIAHIIGYESGDVLRVSGKTGEGVSDLLDEVVRRVPHPQGDPDAPTRAMIFDSVYDIYRGVVTYVRVVDGKISPRERIAMMSTGATYELLEVGIVSPEPKASAGLGVGEVGYLITGVKDVRQSKVGDTVTTVRYGATEPLTGYREPKPMVYSGLYPVDSSDYPSLRDALGKLQLNDAALTYEPETSVALGVGYRCGFLGLLHIDITRERLEREFDLDLISTSPNVVYRVVTEDNTEIVVTNPSDWPEGKIRTVYEPVVKITIIAPSEFIGTIMELCQSRRGELGGMDYLSPERVELRYIMPLGEIIFDFFDSLKSRTRGYASLDYEEAGEQEAQLVKVDILLQGEAVDAFSAIVHKDSASAYGNKMTNKLKELIPRQQFEVPVQAAIGSKVIARENIRAIRKDVLSKCYGGDITRKRKLLEKQKEGKKRMKTIGRVEVPQEAFVAALSADAAGDKDKK
Bibliography
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