Gene ML0634 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameML0634
Gene length891 bp
IdentifierML0634
Location 766711 bp
Protein summary information
Molecular mass33858.4 Da
Isoelectric point9.58
Protein length297 amino acids
Structural information
PFAMPF01255
Orthologs
M. tuberculosis H37RvRv2361c
M. lepromatosis Mx1-22AMLPM_0634
Cross-references
UniProtP38119
Gene OntologyCell division, GO:0007047, Di-trans,poly-cis-decaprenylcistransferase activity, Peptidoglycan biosynthetic process, Regulation of cell shape, Cell cycle
Enzyme Classification2.5.1.31
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionINVOLVED IN THE SYNTHESIS OF DECAPRENYL DIPHOSPHATE, A MOLECULE WHICH HAS A CENTRAL ROLE IN THE BIOSYNTHESIS OF MOST FEATURES OF THE MYCOBACTERIAL CELL WALL. ADDS SEVEN MORE ISOPRENE UNITS TO OMEGA,E, Z-FARNESYL DIPHOSPHATE AND RELEASES DECAPRENYL DIPHOSPHATE.
ProductProbable Long (C50) chain Z-isoprenyl diphosphate synthase (Z-DECAPRENYL DIPHOSPHATE SYNTHASE)
CommentsML0634, len: 296 aa. Probable Long (C50) chain Z-isoprenyl diphosphate synthase (EC 2.5.1.-), highly Similar to UPPS_MYCTU|O05837|Rv2361c Long (C50) chain Z-isoprenyl diphosphate synthase from M. tuberculosis (296 aa), Fasta scores: E(): 3.7e-104, (86.5% identity in 296 aa overlap); and CAD97243|Mb2382c from M. bovis. Similar to several Undecaprenyl pyrophosphate synthetases e.g. UPPS_MICLU|O82827 uppS, undecaprenyl pyrophosphate synthetase from Micrococcus luteus (249 aa), Fasta scores: E(): 5.4e-30, (39.4% identity in 246 aa overlap). Similar to ML2467. Previously sequenced as UPPS_MYCLE|P38119 (296 aa), Fasta scores: E(): 0, (99.7% identity in 296 aa overlap). Contains Pfam match to entry PF01255 UPP_synthetase, Putative undecaprenyl diphosphate synthase. Contains PS01066 Undecaprenyl pyrophosphate synthetase family signature. SEEMS TO BELONG TO THE UPP SYNTHETASE FAMILY.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS766711767601+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0634|ML0634
VVRNERTLKSTDFPQLPPAPDDYPTFPDKSTWPVVFPMLPPSPDGGPRRPPQHTSKAVAPRLSAAQLPTHVAIVMDGNGRWANQRGLHRTEGHKMGEAVVIDVACGAIELGIKWLSLYAFSTENWKRSVEEVRFLMGFNRDVVRRRRENLKEMGVRIRWVGSRPRLWRSVINELAIAEHMTAGNDVITINYCVNYGGRTEIAEATREIARLAAAGRLNPERITESTITRHLQRPDIPDVDLFVRTSGEQRSSNFMLWQAAYTEYIFQDKLWPDYDRRDLWAACEEYASRNRRFGSA
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