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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionNECESSARY FOR THE BIOSYNTHESIS OF PURINES, THYMYDYLATE, METHIONINE, HISTIDINE, PANTOTHENATE, AND FORMYL TRNA-MET [CATALYTIC ACTIVITY: 5,10-METHYLENETETRAHYDROFOLATE + NADP(+) = 5,10-METHENYLTETRAHYDROFOLATE + NADPH] [CATALYTIC ACTIVITY: 5,10-METHENYLTETRAHYDROFOLATE + H(2)O = 10-FORMYLTETRAHYDROFOLATE].
ProductProbable bifunctional protein fold: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase FolD
CommentsML0674, len: 282 aa. Probable folD, bifunctional enzyme include methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5) and methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9), highly similar to O50385|AL123456|Rv3356c Probable folD, bifunctional enzyme from M. tuberculosis (281 aa), Fasta scores: E(): 0, (86.5% identity in 281 aa overlap); CAD95537|3391c from M. bovis (281 aa). Similar to many e.g. FOLD_ECOLI|P24186 folD, bifunctional methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase from Escherichia coli (287 aa), Fasta scores: E(): 0, (40.8% identity in 277 aa overlap). Previously sequenced as O32879|Z98271 (282 aa), Fasta scores: E(): 0, (99.6% identity in 282 aa overlap). Contains Pfam match to entry PF00763 THF_DHG_CYH, Tetrahydrofolate dehydrogenase/cyclohydrolase. SIMILAR TO OTHER DEHYDROGENASE/CYCLOHYDROLASE ENZYMES OR DOMAINS.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS810693811541+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML0674|folD
VGAITLDGKATRDEILIDLKQRVAALTESGRTPGLGTILVGDDPGSHAYVRGKHADCAKVGITSIRRDLPVDITTAVLHDTIEELNANPDCTGYIVQLPLPKYLDENTALERVDPAKDADGLHPTNLGRLVLSTPAPLPCTARGILHLLRRYGVEIAGTHVVIIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRNLAALTKQADIIVAAVGVPHLLTADMVRPGAVVVDVGVSRVETRLVGDVHPDVWEVAGHVSPNPGGVGPLTRVFLLTNVVELAEGRQ
      
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