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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductProbable tryptophanyl-tRNA synthetase TrpS (TRYPTOPHAN--TRNA LIGASE) (TRPRS) (TRYPTOPHAN TRANSLASE)
CommentsML0686, len: 343 aa. Probable trpS, tryptophanyl-tRNA synthetase (EC 6.1.1.2), highly similar to SYW_MYCTU|O53386|Rv3336c trpS, tryptophanyl-tRNA synthetase from M. tuberculosis (336 aa), Fasta scores: E(): 0, (83.8% identity in 339 aa overlap); and CAD95489|Mb3369c from M. bovis (336 aa). Similar to many e.g. SYW_ECOLI|P00954 trpS, tryptophanyl tRNA synthetase from Escherichia coli (334 aa), Fasta scores: E(): 0, (49.6% identity in 335 aa overlap). Previously sequenced as SYW_MYCLE|Q49901 (343 aa), Fasta scores: E(): 0, (100.0% identity in 343 aa overlap). Contains Pfam match to entry PF00579 tRNA-synt_1b, tRNA synthetases class I (W and Y). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS822127823158+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML0686|trpS
MSTATGFSRIFSGVQPTSDSLHLGNALGAITQWVALQYDHPDEYEAFFCVVDLHAITIAQDPETLWRRTLVTAAQYLALGIDPGRAVVFVQSHVPAHTQLAWVLGCFTGFGQASRMTQFKDKALRQGADSTTVGLFTYPVLQAADVLAYDTDLVPVGEDQRQHLELARDLAQRFNSRFPDTFVVPDMFIPKMAAKIYDLADPTSKMSKSASSDAGLINLLDDPALSVKKIRAAVTDSEREIRYDPEVKPGVSNLLNIQSAVTGVDVDTLVQRYVGHGYGDLKKDTAEAVVEFVSPIKDRVDELMADLTELEVVLAVGAQRAQDVAGKTMQRVYDRLGFLPQRG
      
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