Gene ML0697c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable succinate dehydrogenase (flavoprotein subunit) SdhA (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE) |
| Comments | ML0697c, len: 584 aa. Probable sdhA, flavoprotein of succinate dehydrogenase SdhA subunit (EC 1.3.99.1), highly similar to O53370|AL123456|Rv3318 sdhA, succinate dehydrogenase from M. tuberculosis (590 aa), Fasta scores: E(): 0, (92.5% identity in 590 aa overlap); and CAD95440| from M. bovis (590 aa). Similar to many e.g. SW:DHSA_ECOLI (P10444) sdhA, succinate dehydrogenase flavoprotein subunit from Escherichia coli (588 aa), Fasta scores: E(): 0, (48.6% identity in 589 aa overlap). Previously sequenced as Q49924|U00022 (401 aa), Fasta scores: E(): 0, (97.2% identity in 395 aa overlap). Contains Pfam match to entry PF00890 FAD_binding_2, FAD binding domain. Contains PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. COFACTOR: FAD. SIMILAR TO THE FLAVOPROTEIN SUBUNITS OF OTHER SPECIES SUCCINATE DEHYDROGENASE AND OF FUMARATE REDUCTASE. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN, AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 834667 | 836421 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0697c|sdhA
LIQQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCAALANVEDDNWEWHAFDTVKGGDYLADQDAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFNEFYALDLVLTQTPSGPVTTGVVAYELATGDIHVFHTKAVVIATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFHQFHPTGLAGLGILISEAVRGEGGRLLNGENERFMEHYAPTIVDLAPRDIVARSMVLEVLEGRGAGPHKDYVYIDVRHLGEEVLESKLPDITEFSRTYLGVDPVHELVPVYPTCHYVMGGIPTTVTGQVLRDNTSTVPGLYAAGECACVSVHGANRLGTNSLLDINVFGRRSGIAAASYASANDFVDMPPNPAEMVISWVANILSEHGNERVADIRGALQQTMDNNAAVFRTEETLKQALTDIHSLKERYSRITVHDKGKSFNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPHRDDTNYMRHTMAYKQGTDLLSDIALDFKPVVQTRYEPQERKY
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