Gene ML0713 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameglpD
Gene length1758 bp
IdentifierML0713
Location 851949 bp
Protein summary information
Molecular mass63340.4 Da
Isoelectric point6.84
Protein length586 amino acids
Structural information
PFAMPF01266
Orthologs
M. tuberculosis H37RvRv3302c
M. lepromatosis Mx1-22AMLPM_0713
Cross-references
UniProtP53435
Gene OntologyGlycerol-3-phosphate dehydrogenase complex, Glycerol-3-phosphate metabolic process, Oxidation-reduction process, Glycerol-3-phosphate dehydrogenase activity
Enzyme Classification1.1.5.3
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionINVOLVED IN AEROBIC RESPIRATION AND OXYDATION OF GLYCEROL. REDUCES AN ACCEPTOR AND GENERATES GLYCERONE PHOSPHATE FROM Sn-GLYCEROL 3-PHOSPHATE. POSSIBLY PLAY A ROLE IN METABOLISM OF RIBOFLAVIN, FAD,FMN [CATALYTIC ACTIVITY: SN-GLYCEROL 3-PHOSPHATE + ACCEPTOR = GLYCERONE PHOSPHATE + REDUCED ACCEPTOR].
ProductProbable glycerol-3-phosphate dehydrogenase GlpD
CommentsML0713, len: 585 aa. Probable glpd, glycerol-3-phosphate dehydrogenase (EC 1.1.99.5), highly similar to O07168|AL123456|Rv3302c glpD2, glycerol-3-phosphate dehydrogenase from M. tuberculosis (585 aa), Fasta scores: E(): 3e-212, (90.8% identity in 584 aa overlap). Similar to many e.g. GLPD_ECOLI|P13035 glpD, glycerol-3-phosphate dehydrogenase from Escherichia coli (501 aa), Fasta scores: E(): 0, (35.2% identity in 492 aa overlap). Also similar to Q9ZB31|U57100 eriB, erythritol phosphate dehydrogenase from Brucella abortus (502 aa), Fasta scores: E(): 0, (35.4% identity in 483 aa overlap. Previously sequenced as GLPD_MYCLE|P53435 (585 aa), Fasta scores: E(): 0, (99.8% identity in 585 aa overlap). Contains Pfam match to entry PF01224 FAD_Gly3P_dh, FAD-dependent glycerol-3-phosphate dehydrogenase. Contains PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. Contains PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1. BELONGS TO THE FAD-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE FAMILY.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS851949853706+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0713|glpD
VTDLIQAPESEQTWPASALGPQQRAAAWERFGTEQFDVVVIGGGVVGSGCALDAATRGLKVALVEARDLASGTSSRSSKMFHGGLRYLEQLEFGLVREALYERELSLTTLAPHLVKPLPFLFPLTKRWWERPYIAAGIFLYDRLGGAKSVPAQKHLTRAGALRLSPGLKRSSLIGGIRYYDTVVDDARHTLTVARTAAHYGAVVRCSTQVVALLREGDRVIGVRVRDSEDGAVTEIRGHVVVNATGVWTDEIQALSKQRGRFQVRVSKGVHVVVPRDRIVSDVAMILRTKKSVMFIIPWGNHWIIGTTDTDWNLDLAHPAATKADIDYILQTVNTVLATPLTHADIDGVYAGLRPLLAGESDDTSKLTREHAVAVPVAGLVAIAGGKYTTYRVMAADAIDAAVAFVPARVAPSITEKVGLLGADGYFALINQVEHVAALQGLHPYRVRHLLDRYGALIGDVLALAAEAPDLLSPIQEAPGYLKVEARYAVTAEGALHLEDILARRMRVSIEYPHRGVACAREVADVVAPVLGWTAEDIDREVATYNARVEAEVLSQAQPDDVSADMLRASAPEARTKIIEPVSLT
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