Gene ML0726c (bccA)
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN LONG-CHAIN FATTY ACID SYNTHESIS (AT THE FIRST STEP). CARRIES TWO FUNCTIONS: BIOTIN CARBOXYL CARRIER PROTEIN AND BIOTIN CARBOXYLTRANSFERASE [CATALYTIC ACTIVITY: ATP + BIOTIN-CARBOXYL-CARRIER PROTEIN + CO(2) = ADP + ORTHOPHOSPHATE + CARBOXYBIOTIN-CARBOXYL-CARRIER PROTEIN]. |
| Product | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) |
| Comments | ML0726c, len: 598 aa. Probable accA3, bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain (EC 6.3.4.14), highly similar to P96890|AL123456|Rv3285 Probable accA3, bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain from M. tuberculosis (600 aa), Fasta scores: E(): 0, (88.7% identity in 601 aa overlap). Also highly similar to other proteins e.g. P71122|ACCBC ACYL COENZYME A CARBOXYLASE from Corynebacterium glutamicum (Brevibacterium flavum) (591 aa), FASTA scores: opt: 2776, E(): 8.6e-163, (70.202% identity in 594 aa overlap); Q54119|BCPA2 BIOTIN CARBOXYLASE AND BIOTIN CARBOXYL CARRIER PROTEIN from Saccharopolyspora erythraea (Streptomyces erythraeus) (591 aa), FASTA scores: E(): 2.1e-139, (69.192% identity in 594 aa overlap). Previously sequenced as BCCA_MYCLE|P46392 (598 aa), Fasta scores: E(): 0, (99.7% identity in 598 aa overlap). Contains Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzymes. Contains Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase). Contains PS00867 Carbamoyl-phosphate synthase subdomain signature 2. Contains PS00866 Carbamoyl-phosphate synthase subdomain signature 1. Contains PS00188 Biotin-requiring enzymes attachment site. Note previously known as bccA |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 867697 | 869493 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0726c|accA3
VASHASSRIAKVLVANRGEIAVRVIRAARDARLPSVAVYAEPDAEAPHVRLADEAFALGGHTSAESYLDFGKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKNADEVVAFAKEHGVPIAIKAAFGGGGKGMKVARTLEEISELYESAVREATVAFGRGECFVERYLDKPRHVEAQVIADQHGNIVVAGTRDCSLQRRFQKLVEEAPAPFLTDAQRKEIHESAKRICKEAHYYGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETTGIDLVLQQFKIANGEKLELIKDPIPCGHAIEFRINGEDAGRNFLPSPGPVSKFHPPTGPGVRLDSGVETGSVIGGQFDSMLAKLIVHGATRQEALARARRALDEFEVEGLATVIPFHRAVVSDPALIGDNNSFSVHTRWIETEWNNTIEPFIDNQPLDEEDTRPQQTVIVEVDGRRLEVSLPADLALANPAGCNPAGVIRKKPKPRKRGGHTGAATSGDAVTAPMQGTVVKVAVAEGQTVMTGDLVVVLEAMKMENPVTAHKDGIITGLAVEAGTAITQGTVLAEIK
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