Gene ML0731c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameaccD5
Gene length1650 bp
IdentifierML0731c
Location 872009 bp
Protein summary information
Molecular mass59396.3 Da
Isoelectric point5.44
Protein length550 amino acids
Structural information
PFAMPF01039
Orthologs
M. tuberculosis H37RvRv3280
M. lepromatosis Mx1-22AMLPM_0731
Cross-references
UniProtP53002
Gene OntologyPropionyl-coa carboxylase activity, Atp binding
Enzyme Classification6.4.1.3
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE)
CommentsML0731c, len: 549 aa. Probable accD5, propyonyl-CoA carboxylase beta chain 5 (EC 6.4.1.3), highly similar to Rv3280|MTCY71.20|P96885|Z92771 accD5, propyonyl-CoA carboxylase beta chain 5 from Mycobacterium tuberculosis (548 aa), fasta scores: E(): 0, (88.7% identity in 549 aa); and CAD95400|Mb3308 from M. bovis (548 aa). Also highly similar to others e.g. PCCB_SACER|P53003 pccB propionyl-CoA carboxylase beta chain from Saccharopolyspora erythraea (546 aa), fasta scores: E(): 3.2e-158, (69.1% identity in 530 aa); and O87201|DTSR2 DTSR2 PROTEIN INVOLVED IN GLUTAMATE PRODUCTION from Corynebacterium glutamicum (Brevibacterium flavum) (537 aa), FASTA scores: opt: 2604, E(): 5.9e-168, (72.71% identity in 537 aa overlap) (see Kimura et al., 1996). Also similar to ML0102 and ML1657 from M. leprae. Previously sequenced as PCCB_MYCLE|P53002. Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain. BELONGS TO THE ACCD/PCCB FAMILY.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS872009873658-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0731c|accD5
MTSVTDHSAHSMERAAEHTINIHTTAGKLAELHKRTEEALHPVGAAAFEKVHAKGKFTARERIYALLDDDSFVELDALARHRSTNFGLGENRPVGDGVVTGYGTIDGRDVCIFSQDVTVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEGVVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKSGTAHYVASGEQDAFDWVRDVLSYLPSNNFTDAPRYSKPVPHGSIEDNLTAKDLELDTLIPDSPNQPYDMHEVVTRLLDEEEFLEVQAGYATNIVVGLGRIDDRPVGIVANQPIQFAGCLDINASEKAARFVRVCDCFNIPIVMLVDVPGFLPGTEQEYDGIIRRGAKLLFAYGEATVPKITVITRKAYGGAYCVMGSKNMGCDVNLAWPTAQIAVMGASGAVGFVYRKELAQAAKNGANVDELRLQLQQEYEDTLVNPYIAAERGYVDAVIPPSHTRGYIATALHLLERKIAHLPPKKHGNIPL
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