Gene ML0735
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN PURINE BIOSYNTHESIS (SIXTH STEP). POSSESSES AN ATPASE ACTIVITY THAT IS DEPENDENT ON THE PRESENCE OF AIR (AMINOIMIDAZOLE RIBONUCLEOTIDE). THE ASSOCIATION OF PURK AND PURE PRODUCES AN ENZYME COMPLEX CAPABLE OF CONVERTING AIR TO CAIR EFFICIENTLY UNDER PHYSIOLOGICAL CONDITION [CATALYTIC ACTIVITY: 1-(5-PHOSPHORIBOSYL)-5-AMINO-4-IMIDAZOLE-CARBOXYLATE = 1-(5-PHOSPHORIBOSYL)-5-AMINOIMIDAZOLE + CO(2)] |
| Product | Probable phosphoribosylaminoimidazole carboxylase ATPase subunit PurK (AIR CARBOXYLASE) (AIRC) |
| Comments | ML0735, len: 439 aa. Probable purK, phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21), highly similar to Rv3276c|MTCY71.16c|PURK_MYCTU purK, phosphoribosylaminoimidazole carboxylase ATPase subunit from Mycobacterium tuberculosis (429 aa), fasta scores: E(): 0, (76.1% identity in 444 aa). Similar to several e.g. PURK_CORAM|Q44678 phosphoribosylaminoimidazole carboxylase ATPase subunit purK from Corynebacterium ammoniagenes (413 aa), fasta scores: E(): 9.9e-64, (48.3% identity in 404 aa). Previously sequenced as PURK_MYCLE|P46701. Contains Pfam match to entry PF02222 ATP-grasp, ATP-grasp domain. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 875925 | 877244 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0735|purK
MMAVPSRCSLGVAPLVAMVGGGQLARMTHQAAIALGQTLRVLATAADEPAAQVTPDVVIGSHTDLEDLRRVALGADALTFDHEHVPTELLDKLVAEGINVAPSPQALVHAQDKLVMRRRLAALGAAMPRFMALDSVDDLAEIDAFAQRLTGSKDAPMVVKAVRGGYDGRGVQMVRDSAHAREVASGYLVDGMPVLVEERVELRRELSALVARSPFGQGAAWPVVETVQRDGICVLVVAPALALADDLASAAQQLALRLAAELGVVGVFAVELFETADGALLVNELAMRPHNSGHWTMDGARTSQFEQHLRAVLDYPLGETDAVAPVTVMVNVLGAPQPPTLSVVTMDERLHHLFARMPDARVHLYDKVERPGRKVGHINFRGTDKDRKNPTKLRERAELAAHWLSHGQWTDGWDPHRAGDDVVEISLACGGRNDAQRQR
Bibliography
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