Gene ML0737
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable acyl-CoA dehydrogenase FadE25 |
| Comments | ML0737, len: 389 aa. Probable fadE25, Acyl-CoA Dehydrogenase (EC 1.3.99.-), highly similar to Rv3274c|MTCY71.14c|P96879|Z92771 fadE25, Acyl-CoA Dehydrogenase from Mycobacterium tuberculosis (389 aa), fasta scores: E(): 3.5e-155, (92.0% identity in 389 aa). Highly similar to others e.g. Q9RIQ5|AJ250495 fatty acid acyl-CoA dehydrogenase fadE from Streptomyces lividans (385 aa), fasta scores:E(): 3.9e-106, (67.6% identity in 383 aa). Also similar to ML0660, ML0661 and shows weaker similarity to ML2563 from M. leprae. Previously sequenced as ACD_MYCLE|P46703. Contains Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. Contains PS00073 Acyl-CoA dehydrogenases signature 2. Contains PS00072 Acyl-CoA dehydrogenases signature 1. BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 877854 | 879023 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0737|fadE25
MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR
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