Gene ML0758c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namefbiB
Gene length1374 bp
IdentifierML0758c
Location 900394 bp
Protein summary information
Molecular mass48529.4 Da
Isoelectric point5.2
Protein length458 amino acids
Structural information
PFAMPF00881, PF01996
Orthologues
M. tuberculosisRv3262
Cross-references
UniProtQ9CCK2
Gene OntologyCoenzyme f420-0 gamma-glutamyl ligase activity, Coenzyme biosynthetic process, Manganese ion binding, Oxidoreductase activity, Potassium ion binding, Gtp binding
Enzyme Classification6.3.2.-
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable F420 biosynthesis protein FbiB
CommentsML0758c, len: 457 aa. Probable fbiB, F420 biosynthesis protein, equivalent to FBIB F420 biosynthesis protein fbiB from Mycobacterium bovis BCG (see citations below). Highly similar to Rv3262|MTCY71.02|P96867|Z92771 Probable fbiB, F420 biosynthesis protein from Mycobacterium tuberculosis (448 aa), fasta scores: E(): 6.9e-138, (82.2% identity in 445 aa), and to SCE34.18|Q9KZK8|AL353862 putative oxidoreductase from Streptomyces coelicolor (443 aa), fasta scores: E(): 5.4e-65, (50.8% identity in 455 aa); and several hypothetical bacterial proteins. Contains Pfam match to entry PF00881 Nitroreductase, Nitroreductase family. Contains Pfam match to entry PF01996 DUF129, Protein of unknown function.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS900394901767-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0758c|fbiB
VTSSDSHRSAPSPEHGTASTIEILPVAGLPEFRPGDDLSAALAAAAPWLRDGDVVVVTSKVVSKCEGRLVPAPEDTRGRNELRRKLINDETIRVLARKGRTLIIENGLGLVQAAAGVDGSNVGRGELALLPVNPDASAAVLRIGLRAMLGVNVAVVITDTMGRAWRNGQTDVAIGAAGLAVLHNYSGAVDRYGNELVVTEIAVADEVAAATDLVKGKLTAMPVAVVRGLSPTDDGSTAQHLLRNGPDDLFWLGTTEALELGRQQAQLLRRSVRQFSDEPIAAELIETAVAEALTAPAPHHTRPVRFVWLQTPAVRTRLLDRMADKWRLDLASDALPADAIAQRVARGQILYDAPEVIIPFMVPDGAHAYPDAARASAEHTMFIVAVGAAVQALLVALAVRGLGSCWIGSTIFADDLVRAELELPADWEPLGAIAIGYAHEPTDLREPVRVADLLLRK
Bibliography
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