Gene ML0765
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHOSPHOHEXOMUTASE) |
| Comments | ML0765, len: 410 aa. Probable manA, mannose-6-phosphate isomerase (EC 5.3.1.8), highly similar to Rv3255c|MTCY20B11.30c|O05898|Z95121 Probable manA, mannose-6-phosphate isomerase from M. tuberculosis (408 aa), fasta scores: E(): 2.6e-143, (84.4% identity in 411 aa overlap); and CAD95375|Mb3283c from M. bovis (408 aa). Similar to several e.g. Q9KZL9 Mannose-6-phosphate isomerase from Streptomyces coelicolor (383 aa), fasta scores: E(): 6.5e-54, (44.717% identity in 407 aa overlap); and MANA_HUMAN|P34949 mannose-6-phosphate isomerase from Homo sapiens (422 aa), fasta scores: E(): 1.2e-27, (31.0% identity in 432 aa overlap). Contains Pfam match to entry PF01238 PMI_typeI, Phosphomannose isomerase type I. SIMILAR TO FAMILY 1 OF MANNOSE-6-PHOSPHATE ISOMERASES. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 907184 | 908416 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0765|manA
VELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDSVWLQAANGETSLLEALVADPEGQLGSVSRARFGDVLPFLVKVLAADEPLSLQAHPSTKQAVEGYLREERLGIPVSSPERNYRDTSHKPELLVALQSFEALAGFRQSSRTAELLTALAVSDLDPFIHLLSDQSDADGLRALFTTWITAPQTDIDMLVPAVLEGAIAYVSSGATEFLAEVKTVMELGERYPGDAGVLASLLLNRISLTPGEAIFLPAGNLHAYLRGVGVEVMANSDNVLRGGLTPKHVDVPELLRVLDFNPTPEEALRPPTRCEGFAVVYETPTDEFEVALLALDGDYLGHEVDASPHDVSQGPQILLCTEGEITVHGKFQALTVERGMAVWMAADDGPIRLVAQQPAKLFRATVGL
Bibliography
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