Gene ML0771
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | THIOESTER HYDROLASE WHICH ACTING ON ETHER BOUNDS. COULD BE INVOLVED IN METHIONINE AND SELENOAMINO ACID METABOLISMS. ALSO INVOLVED IN ACTIVATED METHYL. CYCLE ADENOSYLHOMOCYSTEINE IS A COMPETITIVE INHIBITOR OF S-ADENOSYL-L-METHIONINE-DEPENDENT METHYL TRANSFERASE REACTIONS; THEREFORE ADENOSYLHOMOCYSTEINASE MAY PLAY A KEY ROLE IN THE CONTROL OF METHYLATIONS VIA REGULATION OF THE INTRACELLULAR CONCENTRATION OF ADENOSYLHOMOCYSTEINE [CATALYTIC ACTIVITY: S-ADENOSYL-L-HOMOCYSTEINE + H(2)O = ADENOSINE + L-HOMOCYSTEINE]. |
| Product | putative S-adenosyl-L-homocysteine hydrolase SahH |
| Comments | ML0771, len: 492 aa. Probable sahH, adenosylhomocysteinase (EC 3.3.1.1), highly similar to Rv3248c|MTCY20B11.23c|SAHH_MYCTU|O08364 Probable sahH, adenosylhomocysteinase from M. tuberculosis (495 aa), fasta scores: E(): 1.1e-187, (91.4% identity in 489 aa), and CAD95368|Mb3276c from M. bovis (495 aa). Also highly similar to other adenosylhomocysteinases e.g. SAHH_TRIVA|P51540 adenosylhomocysteinase from Trichomonas vaginalis (486 aa), fasta scores: E(): 3.2e-121, (62.3% identity in 478 aa). Contains Pfam match to entry PF00670 AdoHcyase, S-adenosyl-L-homocysteine hydrolase. Contains PS00739 S-adenosyl-L-homocysteine hydrolase signature 2. Contains PS00738 S-adenosyl-L-homocysteine hydrolase signature 1. BELONGS TO THE ADENOSYLHOMOCYSTEINASE FAMILY. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 913624 | 915102 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0771|sahH
MTTTENSLMPDVRNGIDFKVADLSLANFGRKELDLAEYEMPGLMSLRHEYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPYGTPEEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPVNMILDDGGDATMLVLRGVQYEKAGVVPPAEVDDSAEWKVFLNLLRKRFETDKGKWTKIAKSVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDSLIGGKNVLICGYGDVGKGCAEAAKGQGARVTITEIDPINALQALMEGFDVKRVEDVIADSDIVVTATGNKDIILLEHMKAMKDHAILGNIGHFDNEIDMAALERSGATRLNIKPQVDLWTFGDSGKSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDDYDNEVYRLPKHLDEKVARVHVEALGGQLTKLTKDQAEYLGVDVDGPFKPDHYRY
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