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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionTHIOESTER HYDROLASE WHICH ACTING ON ETHER BOUNDS. COULD BE INVOLVED IN METHIONINE AND SELENOAMINO ACID METABOLISMS. ALSO INVOLVED IN ACTIVATED METHYL. CYCLE ADENOSYLHOMOCYSTEINE IS A COMPETITIVE INHIBITOR OF S-ADENOSYL-L-METHIONINE-DEPENDENT METHYL TRANSFERASE REACTIONS; THEREFORE ADENOSYLHOMOCYSTEINASE MAY PLAY A KEY ROLE IN THE CONTROL OF METHYLATIONS VIA REGULATION OF THE INTRACELLULAR CONCENTRATION OF ADENOSYLHOMOCYSTEINE [CATALYTIC ACTIVITY: S-ADENOSYL-L-HOMOCYSTEINE + H(2)O = ADENOSINE + L-HOMOCYSTEINE].
Productputative S-adenosyl-L-homocysteine hydrolase SahH
CommentsML0771, len: 492 aa. Probable sahH, adenosylhomocysteinase (EC 3.3.1.1), highly similar to Rv3248c|MTCY20B11.23c|SAHH_MYCTU|O08364 Probable sahH, adenosylhomocysteinase from M. tuberculosis (495 aa), fasta scores: E(): 1.1e-187, (91.4% identity in 489 aa), and CAD95368|Mb3276c from M. bovis (495 aa). Also highly similar to other adenosylhomocysteinases e.g. SAHH_TRIVA|P51540 adenosylhomocysteinase from Trichomonas vaginalis (486 aa), fasta scores: E(): 3.2e-121, (62.3% identity in 478 aa). Contains Pfam match to entry PF00670 AdoHcyase, S-adenosyl-L-homocysteine hydrolase. Contains PS00739 S-adenosyl-L-homocysteine hydrolase signature 2. Contains PS00738 S-adenosyl-L-homocysteine hydrolase signature 1. BELONGS TO THE ADENOSYLHOMOCYSTEINASE FAMILY.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS913624915102+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML0771|sahH
MTTTENSLMPDVRNGIDFKVADLSLANFGRKELDLAEYEMPGLMSLRHEYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPYGTPEEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPVNMILDDGGDATMLVLRGVQYEKAGVVPPAEVDDSAEWKVFLNLLRKRFETDKGKWTKIAKSVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDSLIGGKNVLICGYGDVGKGCAEAAKGQGARVTITEIDPINALQALMEGFDVKRVEDVIADSDIVVTATGNKDIILLEHMKAMKDHAILGNIGHFDNEIDMAALERSGATRLNIKPQVDLWTFGDSGKSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDDYDNEVYRLPKHLDEKVARVHVEALGGQLTKLTKDQAEYLGVDVDGPFKPDHYRY
      
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