Gene ML0773
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | probable two-component sensory transduction transcriptional regulatory protein MtrA |
| Comments | ML0773, len: 228 aa. Probable mtrA, transcriptional activator, response regulator (see citations below), highly similar to Rv3246c|MTCY20B11.21c|Q50447|Z95121 mtrA, transcriptional activator from Mycobacterium tuberculosis (228 aa), fasta scores: E(): 1.3e-92, (98.7% identity in 228 aa); and CAD93364|Mb3274c from M. bovis (227 aa). Also highly similar to others e.g. AFQ1_STRCO|Q04942 transcriptional regulatory protein afsQ1 from Streptomyces coelicolor (225 aa), fasta scores: E(): 1.7e-40, (47.1% identity in 221 aa). Also similar to ML0174, ML1286, ML2123 and ML2439 from M. leprae. Contains Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain. SIMILAR TO BACTERIAL REGULATORY PROTEINS INVOLVED IN SIGNAL TRANSDUCTION. THE N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS. Experiments in M. tuberculosis have showed mtrA is differentially expressed in virulent and avirulent strains during growth in macrophages. |
| Functional category | Regulatory proteins |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 915870 | 916556 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0773|mtrA
MDIMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRRNDDEPAEMLSIADVDIDVPAHKVTRNGEHISLTPLEFDLLVALARKPRQVFTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVGYKAGPP
Bibliography
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