Gene ML0774
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | probable two-component sensory transduction histidine kinase MtrB |
| Comments | ML0774, len: 562 aa. Probable mtrB, sensor-like histidine kinase (EC 2.7.3.-) (see citations below), highly similar to Q50496|U14909|Rv3245c mtrB, sensor-like histidine kinase Mycobacterium (567 aa), fasta scores: E(): 2.2e-197, (88.3% identity in 566 aa); and CAD95365|Mb3273c from M. bovis (567 aa). Also similar to others e.g. Q9KYW9|SCE33.14c PUTATIVE TWO-COMPONENT SYSTEM HISTIDINE KINASE from Streptomyces coelicolor (688 aa), fasta scores: E(): 5.1e-78, (46.507% identity in 544 aa overlap). And similar to ML0175, ML2124 and ML2440 from M. leprae. Contains hydrophobic, possible membrane-spanning region. Contains Pfam match to entry PF00672 DUF5, Domain found in bacterial signal proteins. Contains Pfam match to entry PF00512 signal, Histidine kinase. SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE KINASES. |
| Functional category | Regulatory proteins |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 916684 | 918372 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0774|mtrB
VIFSSRRRIRGRWGRSGPMMRGMGALTRVVGVVWRRSLQLRVVALTFGLSLAVILALGFVLTSQLTSRVLDVKVRVAIEQIERARTTVTGIVNGEETRSLDSSLQLARNTLTSKTDPTSGAGLVGAFDAVLIVPGDGPRTATTAGPVDQVPNSLRGFIKAGQAAYQYATVHTEGFSGPALIIGTPTSSQVTNLELYLIFPLKNEQATVTLVRGTMATGGMVLLVLLSGIALLVSRQVVVPVRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLSRQITQLEEFGNLQRRFTSDVSHELRTPLTTVRMAADLIYDHSSDLDPTLRRSTELMVSELDRFETLLNDLLEISRHDAGVAELSVEAVDLRVMVNNALGNVGHLAEEAGIELLVDMPVDEVIAEVDARRVERILRNLIANAIDHSEHKPVRIRMAADEDTVAVTVRDYGIGLRPGEEKLVFSRFWRSDPSRVRRSGGTGLGLAISIEDARLHQGRLEAWGEPGQGACFRLTLPLVRGHKVTTSPLPMKPILQPSPQASTAGQQHGTQRQRLREHAERSR
Bibliography
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