Gene ML0779 (secA) in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namesecA1
Gene length2823 bp
IdentifierML0779
Location 921723 bp
Protein summary information
Molecular mass105496.0 Da
Isoelectric point5.01
Protein length941 amino acids
Structural information
PFAMPF01043, PF07516, PF07517
Orthologs
M. tuberculosis H37RvRv3240c
M. lepromatosis Mx1-22AMLPM_0779
Cross-references
UniProtP57996
Gene OntologyCytoplasm, Intracellular protein transmembrane transport, Plasma membrane, Protein binding, Protein import, Protein targeting, Atp binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE PREPROTEIN TRANSLOCASE SECA1 SUBUNIT
CommentsML0779, len: 940 aa. Probable secA1, preprotein translocase subunit, component of secretion apparatus (see citations below), highly similar to Rv3240c|MTCY20B11.15c|SEA1_MYCTU|O05885 Probable secA1, preprotein translocase subunit from Mycobacterium tuberculosis (949 aa), fasta scores: E(): 0, (87.5% identity in 949 aa); and CAD95360|Mb3268c from M. bovis (949 aa). Highly similar to many e.g. P71533|SECA_MYCSM Preprotein translocase secA subunit from M. smegmatis (957 aa), fasta scores: E(): 0, (77.651% identity in 962 aa overlap). Also similar to ML2082 from M. leprae. Contains Pfam match to entry PF01043 SecA_protein, SecA protein, amino terminal region. Contains PS01312 Protein secA signatures. BELONGS TO THE SECA FAMILY. PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA, SECD|ML0487, SECE|ML1907, SECF|ML0488, SECG|ML0577 AND SECY|ML1833.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS921723924545+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0779|secA1
VLSKLLRLGEGRIVKRLKRVAEYVNTLSDNVEKLTDVELKAKTDEFKQRLADEKNPESLDDLLPEAFAVAREAAWRVLDQRPFDVQVMGGAALHLGNVAEMKTGEGKTLTCVLPAYLNALAGKGVHIVTVNDYLAKRDSEWMGRVHRFLGLQVGVILASMTPDERRVAYNADITYGTNNEFGFDYLRDNMAHSLDDLVQRGHSYAIVDEVDSILIDEARTPLIISGSADGASNWYTEFARLVRLMDKDVHYEVDLRKRTVGVHEKGMEFVEDQLGIDNLYEVANSPLVSYLNNALKAKELFNRDKDYIVRDGEVLIVDEFTGRVLIGRRYNEGMHQAIEAKEHVEIKAENQTLATITLQNYFRLYDKLAGMTGTAQTEAAELHEIYKLGVVAIPTNKPMIREDRSDLIYKTEEAKYMAVVDDVAERYEKGQPVLIGTTSVERSEYLSRQFTKRHIPHNVLNAKYHEQEAGIVAVAGRRGGVTVATNMAGRGTDIVLGGNVDFLTDQRLRRRGLDPVETPDEYEQAWHSELPKVKEEAGQEAAEVIEAGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLGDELMRRFHGATLEALLTRLNLPDDVPIEAKMVTRAIKSAQTQVEQQNFEVRKNVLKYDEVMNQQRKVIYAERRRILEGESLQQQALGMVRDVITAYIDGATTDSYVEDWDLDALWSALGTLYPVGIKHESLTHADEDSECDELSRDELLEALLIDAQHAYAAREAELAELAGEGAMRQLERNVLLNVVDRKWREHLYEMDYLKEGIGLRAMAQRDPLVEYQREGYDMFMAMLDGVKEESVGFLFNLAVEAVPASHVAPVEIPEGFTGLVADVEAIRPREEASSALRTKDIDNESTGLTYSGPSEDGSTQVQLNSGGGQKTPAGIPVGASRRERREAARRRGRGAKPSRSVKKR
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