Gene ML0792c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN THE BIOSYNTHESIS OF CHORISMATE WITHIN THE BIOSYNTHESIS OF AROMATIC AMINO ACIDS (THE SHIKIMATE PATHWAY). ACTS IN THE SIXTH STEP OF THIS PATHWAY. [CATALYTIC ACTIVITY: PHOSPHOENOLPYRUVATE + 3-PHOSPHOSHIKIMATE = ORTHOPHOSPHATE + O(5)-(1-CARBOXYVINYL)-3-PHOSPHOSHIKIMATE]. |
| Product | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS) |
| Comments | ML0792c, len: 430 aa. Probable aroA, 3-phosphoshikimate 1-carboxyvinyl transferase (EC 2.5.1.19) (see citation below), highly similar to Rv3227|MTCY20B11.02|AROA_MYCTU|P22487 aroA, 3-phosphoshikimate 1-carboxyvinyl transferase from Mycobacterium tuberculosis (450 aa), fasta scores: E(): 2e-132, (79.0% identity in 428 aa); and CAD95348|Mb3256 from M. bovis (450 aa). Similar to several e.g. Q9K4A7|ARA2_STRCO 3-phosphoshikimate 1-carboxyvinyl transferase from Streptomyces coelicolor (438 aa), fasta scores: E(): 1.2e-69, (53.009% identity in 432 aa overlap). Contains Pfam match to entry PF00275 EPSP_syntase, EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase). Contains PS00885 EPSP synthase signature 2. BELONGS TO THE EPSP SYNTHASE FAMILY. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 935509 | 936801 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0792c|aroA
VSIESWTAPVASTPVQANVTIPGSKSQTNRALMLAALAAAQGQGTSTIGGALRSRDTELMISALRTLGLHVDEAGSVLTVNGRITPGEDAQVDCGLAGTVLRFVPPLAALSANPVTFDGDEQARARPITPLLDALRGLGVPVDGVGLPFQVQGSGSVAGGTVAIDASASSQFVSGLLLCAASFTQGVTVQHTGSPVPSAPHIAMTVMMLRQAGVQVDDSVGNRWQVRPGTVAARHWVVEPDLTNAVAFLAAAAVSGGTVRITGWPKTSVQPADNILNILFRLNVVVNQTDSFLEVQGSTVYDGFDVDLRDVGELTPSVAALAALATPGSVSQLHGIAHLRGHETDRLAALSTEINRLGGDCQETSDGLIITATPLRPGVWRAYADHRMAMAGAIVGLRVSGVEVDDIGATHKTLPQFPQLWANMLKRSTG
Bibliography
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