Gene ML0792c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namearoA
Gene length1293 bp
IdentifierML0792c
Location 935509 bp
Protein summary information
Molecular mass44525.4 Da
Isoelectric point5.81
Protein length431 amino acids
Structural information
PFAMPF00275
Orthologues
M. tuberculosisRv3227
Cross-references
UniProtQ9CCI3
Gene OntologyAromatic amino acid family biosynthetic process, Cytoplasm, 3-phosphoshikimate 1-carboxyvinyltransferase activity
Enzyme Classification2.5.1.19
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionINVOLVED IN THE BIOSYNTHESIS OF CHORISMATE WITHIN THE BIOSYNTHESIS OF AROMATIC AMINO ACIDS (THE SHIKIMATE PATHWAY). ACTS IN THE SIXTH STEP OF THIS PATHWAY. [CATALYTIC ACTIVITY: PHOSPHOENOLPYRUVATE + 3-PHOSPHOSHIKIMATE = ORTHOPHOSPHATE + O(5)-(1-CARBOXYVINYL)-3-PHOSPHOSHIKIMATE].
Productprobable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS)
CommentsML0792c, len: 430 aa. Probable aroA, 3-phosphoshikimate 1-carboxyvinyl transferase (EC 2.5.1.19) (see citation below), highly similar to Rv3227|MTCY20B11.02|AROA_MYCTU|P22487 aroA, 3-phosphoshikimate 1-carboxyvinyl transferase from Mycobacterium tuberculosis (450 aa), fasta scores: E(): 2e-132, (79.0% identity in 428 aa); and CAD95348|Mb3256 from M. bovis (450 aa). Similar to several e.g. Q9K4A7|ARA2_STRCO 3-phosphoshikimate 1-carboxyvinyl transferase from Streptomyces coelicolor (438 aa), fasta scores: E(): 1.2e-69, (53.009% identity in 432 aa overlap). Contains Pfam match to entry PF00275 EPSP_syntase, EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase). Contains PS00885 EPSP synthase signature 2. BELONGS TO THE EPSP SYNTHASE FAMILY.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS935509936801-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0792c|aroA
VSIESWTAPVASTPVQANVTIPGSKSQTNRALMLAALAAAQGQGTSTIGGALRSRDTELMISALRTLGLHVDEAGSVLTVNGRITPGEDAQVDCGLAGTVLRFVPPLAALSANPVTFDGDEQARARPITPLLDALRGLGVPVDGVGLPFQVQGSGSVAGGTVAIDASASSQFVSGLLLCAASFTQGVTVQHTGSPVPSAPHIAMTVMMLRQAGVQVDDSVGNRWQVRPGTVAARHWVVEPDLTNAVAFLAAAAVSGGTVRITGWPKTSVQPADNILNILFRLNVVVNQTDSFLEVQGSTVYDGFDVDLRDVGELTPSVAALAALATPGSVSQLHGIAHLRGHETDRLAALSTEINRLGGDCQETSDGLIITATPLRPGVWRAYADHRMAMAGAIVGLRVSGVEVDDIGATHKTLPQFPQLWANMLKRSTG
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