Gene ML0839c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE CYSTEINE SYNTHASE A CYSK (O-ACETYLSERINE SULFHYDRYLASE A) (O-ACETYLSERINE (THIOL)-LYASE A) (CSASE A) |
| Comments | ML0839c, len: 310 aa. Probable cysK1, cysteine synthase A (EC 4.2.99.8). Similar to Mycobacterium tuberculosis cysteine synthase A cysK or Rv2334 or MTCY98.03 SW:CYSK_MYCTU (P95230) (310 aa) fasta scores: E(): 0, 85.8% identity in 310 aa, and to Spinacia oleracea cysteine synthase, chloroplast precursor cysK SW:CYSL_SPIOL (P32260) (383 aa) fasta scores: E(): 0, 59.2% identity in 309 aa. Previously sequenced as SW:CYSK_MYCLE (O32978). Also similar to ML2396 from M. leprae. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme. Contains PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. BELONGS TO THE CYSTEINE SYNTHASE/CYSTATHIONINE BETA-SYNTHASE FAMILY. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 996359 | 997291 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0839c|cysK
MSIAEDVTQLVGNTPLVRLRRVTEGALADVVAKLESFNPANSVKDRIGVAMIDTAEEAGLIKPDTVILEPTSGNTGIALAMVCAARGYHCVLTMPETMSIERRMLLRAYGAELILTPGADGMSGAIAKAEELAKSDKRYFIPQQFENPANPAIHAATTAEEVWRDTDGKVDIFVSGIGTGGTITGVARIIKERRPATQFVAVEPAASPVLSGGQKGPHPIQGIGAGFVPSVLVLDLVDEIVTVGNEEALDLARRLAKEEGLLVGISAGAAVCAALHVARRPENTGKLIVVVLPDFGERYLSTMLFADLAN
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