Gene ML0854
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN mRNA DEGRADATION. HYDROLYSES SINGLE-STRANDED POLYRIBONUCLEOTIDES PROCESSIVELY IN THE 3' TO 5' DIRECTION. INVOLVED IN THE RNA DEGRADOSOME, A MULTI-ENZYME COMPLEX IMPORTANT IN RNA PROCESSING AND MESSENGER RNA DEGRADATION [CATALYTIC ACTIVITY: RNA(N+1) + PHOSPHATE = RNA(N) + A NUCLEOSIDE DIPHOSPHATE]. |
| Product | BIFUNCTIONAL PROTEIN POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE GPSI: GUANOSINE PENTAPHOSPHATE SYNTHETASE + POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE (POLYNUCLEOTIDE PHOSPHORYLASE) (PNPASE) |
| Comments | ML0854, len: 773 aa. Probable gpsI, polyribonucleotide nucleotidyltransferase (EC 2.7.7.8; 2.7.6.-). Similar to Mycobacterium tuberculosis guanosine pentaphosphate synthetase / polyribonucleotide nucleotidyltransferase gpsI or Rv2783c or MTV002.48C TR:O33325 (EMBL:AL008967) (752 aa) fasta scores: E(): 0, 90.0% identity in 757 aa, to Streptomyces antibioticus guanosine pentaphosphate synthetase gpsI TR:Q53597 (EMBL:U19858) (740 aa) fasta scores: E(): 0, 67.2% identity in 751 aa and to Bacillus subtilis polyribonucleotide nucleotidyltransferase pnpA or comR SW:PNPA_BACSU (P50849) (704 aa) fasta scores: E(): 0, 45.0% identity in 723 aa. Previously sequenced as TR:O32966 (EMBL:Z98741). Contains Pfam match to entry PF00013 KH-domain, KH domain. Contains 2 Pfam matches to entry PF01138 RNase_PH, 3' exoribonuclease family. Contains Pfam match to entry PF00575 S1, S1 RNA binding domain. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1013842 | 1016163 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0854|gpsI
MSVAEIEEGVFEATVTIDNGSFGTRAIRFETGRLALQAAGAVVAYLDADNMLLSATTASKNPKEQFDFFPLTVDVEERMYAAGRIPGSFFRREGRPSTDAILTCRLIDRPLRPSFVDGLRNEIQVVVTILSVDPNDLYDVLAINAASASTQLGGLPFSGPIGGVRVALIDGTWVAFPTVEQLERAVFDMVIAGRIVGTDDEGKPDVAIMMVEAEATENVIELVECGAQAPTESIVAQGLEVAKPFIAALCTAQQELADVVSSRQAKPPVEYPTFPDYGDDVYYSVASMATDELAAALTIGAKLERDQRTNEIKTQVLERLAGTYEGREKELGAAFRSLTKKLVRQRILTNHFRIDGRGITDIRALSAEVAVVPRAHGSALFERGETQILGVTTLDMVKMAQQIDSLGPETSKRYMHHYNFPPFSTGETGRVGSPKRREIGHGALAERALVPVLPSVEEFPYAIRQVSEALGSNGSTSMGSVCASTLALLNAGVPLKAPVAGIAMGLVSDDVEFDGGTERRFVTLTDILGAEDAFGDMDFKCAGTKDFVTALQLDTKLDGIPSQVLAGALAQAKDARLTILEVMAEAIDRPDEMSPYAPRVITIKVPVDKIGEVIGPKGKVINAITEETGAQISIEDDGTVFVGATDGLSAQAAINKINAIANPQLPTVGERFLGTVVKITEFGAFVSLLPGRDGLVHISKLGKGKRIAKVEDVVNVGDKLRVEIADIEKRGKISLVLVADDDSATVPAAPADAGAAQEFGSGTAPADAATASS
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