Gene ML0858c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namelipA
Gene length945 bp
IdentifierML0858c
Location 1020472 bp
Protein summary information
Molecular mass35087.9 Da
Isoelectric point8.2
Protein length315 amino acids
Structural information
PFAMPF04055
Orthologues
M. tuberculosisRv2218
Cross-references
UniProtO32962
Gene OntologyCytoplasm, Iron ion binding, Lipoate biosynthetic process, Lipoate synthase activity, 4 iron, 4 sulfur cluster binding
Enzyme Classification2.8.1.8
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable lipoate biosynthesis protein A LipA
CommentsML0858c, len: 314 aa. Probable lipA, lipoic acid synthetase. Similar to Mycobacterium tuberculosis lipoic acid synthetase lipA or Rv2218 or MTCY190.29 SW:LIPA_MYCTU (Q10380) (311 aa) fasta scores: E(): 0, 86.5% identity in 310 aa. Similar to many e.g. Escherichia coli lipoic acid synthetase lipA or lip SW:LIPA_ECOLI (P25845; P77595) (321 aa) fasta scores: E(): 0, 42.5% identity in 294 aa. Previously sequenced as SW:LIPA_MYCLE (O32962).
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS10204721021416-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0858c|lipA
VTVAPEDCRLLRLEVRNAQTPIERKPPWIKTRARMGPEYTALKNLVRRVALHTVCEEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQIDTGKPAALDRDEPRRVAESVQTMGLRYTTVTGVARDDLPDGGAWLYATTVRAIKELNPSTGVELLIPDFNGQPARLAEVFDSRPQVLAHNVETVPRIFKRIRPAFTYQRSLDVLTAAREAGLVTKSNLILGLGETADEVRTALADLRKTGCDIVTITQYLRPSMRHHPVERWVRPEEFVEYTQYAEGLGFSGVLGGPLVRSSYRAGRLYEQAAGTRTVGTSVSR
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