Gene ML0862 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameephD
Gene length1791 bp
IdentifierML0862
Location 1024956 bp
Protein summary information
Molecular mass64907.1 Da
Isoelectric point9.97
Protein length597 amino acids
Structural information
PFAMPF00106, PF00561
Orthologs
M. tuberculosis H37RvRv2214c
M. lepromatosis Mx1-22AMLPM_0862
Cross-references
UniProtO32958
Gene OntologyMetabolic process, Oxidoreductase activity, Binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPossible short-chain dehydrogenase EphD
CommentsML0862, len: 596 aa. Possible ephD, short-chain dehydrogenase. Similar to Mycobacterium tuberculosis probable oxidoreductase ephD or Rv2214c or MTCY190.25C SW:EPHD_MYCTU (Q10402) (592 aa) fasta scores: E(): 0, 80.4% identity in 596 aa. Similar to many putative oxidorecuctases e.g. Streptomyces coelicolor putative oxidoreductase SCD78.21C TR:Q9ZBX8 (EMBL:AL034355) (585 aa) fasta scores: E(): 0, 42.4% id in 582 aa. C-terminal half is similar to Pseudomonas paucimobilis C alpha-dehydrogenase ligD SW:LIGD_PSEPA (Q01198) (305 aa) fasta scores: E(): 1.1e-15, 26.8% id in 269 aa. Previously sequenced as TR:O32958 (EMBL:Z98741). Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.
Functional categoryVirulence, detoxification, adaptation
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS10249561026746+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0862|ephD
MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWDGVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALARRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIRVI
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