Gene ML0896 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namearoG
Gene length1389 bp
IdentifierML0896
Location 1061590 bp
Protein summary information
Molecular mass50201.8 Da
Isoelectric point5.43
Protein length463 amino acids
Structural information
PFAMPF01474
Orthologs
M. tuberculosis H37RvRv2178c
M. lepromatosis Mx1-22AMLPM_0896
Cross-references
UniProtO69569
Gene OntologyAromatic amino acid family biosynthetic process, 3-deoxy-7-phosphoheptulonate synthase activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG (DAHP synthetase, phenylalanine-repressible)
CommentsML0896, len: 462 aa. Probable aroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (EC 4.1.2.15). Highly similar to many others e.g. Mycobacterium tuberculosis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase TR:O53512 (EMBL:AL021957) (462 aa), Fasta scores: E(): 0, 89.7% identity in 465 aa overlap; and similar to many plant DAHP synthetase family proteins e.g. Arabidopsis thaliana SW:AROF_ARATH (SW:P29976) (525 aa), Fasta scores: E(): 0, 49.0% identity in 441 aa overlap. Identical to the previously sequenced Mycobacterium leprae 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase TR:O69569 (EMBL:AL022602) (462 aa), Fasta scores: E(): 0, 100.0% identity in 462 aa overlap. Contains Pfam match to entry PF01474 DAHP_synth_2, Class-II DAHP synthetase family.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS10615901062978+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0896|aroG
MNWTVDIPIDQLPPLPADLRARLDAALAKPAAQQPSWPTDQAAAMRTVLESVPPVTVPSEIIRLQEQLALVANGKAFLLQGGDCAETFVDNTEPHIRSNVRTLLQMAVVLTYGASLPVVKVARIAGQYAKPRSADVDALGLKSYRGDMINGFAPDAAAREHDPSRLVRAYANSSAAMNLVRALTSSGLASLHLVHDWNREFVRTSPAGARYEALAGEIGRGLAFMSACGVADRNLQTAEIYASHEALVLDYERAMLRLAGAPEGPDDGLQLYDLSAHTVWIGERTRQLDGAHVAFAEVIANPIGVKMGATMTPELAVEYVERLDPHNKPGRLTLVSRLGNNKVRDVLPPIVEKVKATGHQVIWQCDPMHGNTHESSTGYKTRHFDRVVDEVQGFFEVHRALGTYPGGIHVEITGEDVTECLGGAQDISDTDLAGRYETACDPRLNTQQSLELAFLVAEMLRD
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