Gene ML0897c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE L PKNL (PROTEIN KINASE L) (STPK L) |
| Comments | ML0897c, len: 400 aa. Probable pknL, transmembrane serine/threonine-protein kinase (EC 2.7.1.-). Identical to the previously sequenced Mycobacterium leprae putative serine/threonine protein kinase TR:O69568 (EMBL:AL022602) (400 aa), Fasta scores: E(): 0, 99.8% identity in 400 aa overlap. Also highly similar to many other putative serine/threonine protein kinases e.g. from Mycobacterium tuberculosis: Rv2176 TR:O53510 (EMBL:AL021957) (399 aa), Fasta scores: E(): 0, 75.3% identity in 400 aa overlap and SW:PKNB_MYCTU (SW:P71584) (626 aa), Fasta scores: E(): 2e-31, 39.5% identity in 311 aa overlap. Also similar to ML0016 and ML0017 from M. leprae. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain. Contains PS00108 Serine/Threonine protein kinases active-site signature. Contains PS00107 Protein kinases ATP-binding region signature. BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES |
| Functional category | Regulatory proteins |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1062991 | 1064193 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML0897c|pknL
LLDGRYLLKAKIGNGGTATVYRGVDIRLDRPVAVKVMDSRYTGDEQLLTRFQLEARSVARLKDPGLVAVYDQGIDARHPFLVMELIEGGTLRELLAERGPMPPHAVVAVLRPVLGGLAAAHRAGLVHRDVKPENILISDDGDVKIADFGLVRAVAAAGITSTSVILGTVAYLSPEQVRDGDASPRSDVYSAGIMTYELLTGHTPFTGDSALSIAYQRLEIDVPRASTVITGVPQQFDELVARATVRDPSGRYADAIEMAAQVDSIAEELALPPFRVPAPRNTAQYRSAALHRGHMVERPVEQQVQPVVNAPMPHSTRQFTRRLRDCSAPRRPARPDIDSPEEYEYEPVPDRFAGIAISEFIWARQHARRMVLIWVGVVVAIAGLVATVAWTIGSHLSGLL
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