Gene ML0910 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemurF
Gene length1554 bp
IdentifierML0910
Location 1077593 bp
Protein summary information
Molecular mass52874.0 Da
Isoelectric point5.58
Protein length518 amino acids
Structural information
PFAMPF01225, PF02875, PF08245
Orthologs
M. tuberculosis H37RvRv2157c
M. lepromatosis Mx1-22AMLPM_0910
Cross-references
UniProtO69556
Gene OntologyUdp-n-acetylmuramoyl-tripeptide-d-alanyl-d-alanine ligase activity, Udp-n-acetylmuramoylalanyl-d-glutamyl-2,6-diaminopimelate-d-alanyl-d-alanine ligase activity, Cell cycle, Cell division, GO:0007047, Cytoplasm, Peptidoglycan biosynthetic process, Regulation of cell shape, Atp binding
Enzyme Classification6.3.2.10
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbableUDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF
CommentsML0910, len: 517 aa. Probable murF, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase (EC 6.3.2.15). Identical to the previously sequenced Mycobacterium leprae hypothetical protein UDP-N-acetylmuramoylalanyl-D-glutamyl -2,6-diaminopimelate--D-alanyl-D-alanyl ligase TR:O69556 (EMBL:AL022602) (517 aa), Fasta scores: E(): 0, 100.0% identity in 517 aa overlap. Also highly similar to MurF orthologues from Mycobacterium tuberculosis Rv2157c SW:MURF_MYCTU (SW:O06220) (510 aa), Fasta scores: E(): 0, 75.5% identity in 531 aa overlap and Escherichia coli SW:MURF_ECOLI (SW:P11880) (452 aa), Fasta scores: E(): 1.7e-09, 31.0% identity in 519 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS10775931079146+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0910|murF
MIDLTVARVTEIVGGALVDISPEEAAERRVTGSVEFDSRAVGPGGLFLALPGARSDGHDHAASAIAAGAVAVLAARPVGVPAIVVAPDPRTGDGGLTGVLEHDADGSGAAVLAALAKLAKAVAAELVAGGLTIIGITGSSGKTSTKDLVAVVLELLGEVVAPPESFNNELGHPWTVLRATRSTDYLILEMSARRPGNIAALAAIAPPKIGVVLNVGTAHLGEFGSREAIARTKTELPQAIMQSGVVILNVDDPAVAAMADATVARVIRVSRGSYSHPGSPNSPDVWTGPVSLDELARPRFTLHTRDPRAGATEIQLGVYGDHQVANALCAAAVGLECGASVEEVAVALAATGPVSRHRMQVTTRADGVTVIDDTYNANPDSMRAGLQALAWIAHGGTHDKNQPGSCARRSWAVLGEMAELGEDSITEHDRIGRLAVRLDVSRLVVVGGGRSINAMHRGAVMEGSWGLETVNVADPAAALTLLRAEVRPGDVVLIKASHSVGLGALADVLVGDGAIRP
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