Gene ML0914 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemurG
Gene length1224 bp
IdentifierML0914
Location 1083304 bp
Protein summary information
Molecular mass42390.7 Da
Isoelectric point10.57
Protein length408 amino acids
Structural information
PFAMPF03033, PF04101
Orthologs
M. tuberculosis H37RvRv2153c
M. lepromatosis Mx1-22AMLPM_0914
Cross-references
UniProtO69552
Gene OntologyUdp-n-acetylgalactosamine biosynthetic process, Carbohydrate binding, Cell cycle, Cell division, GO:0007047, Lipid glycosylation, Peptidoglycan biosynthetic process, Plasma membrane, Regulation of cell shape, Undecaprenyldiphospho-muramoylpentapeptide beta-n-acetylglucosaminyltransferase activity, Gram-negative-bacterium-type cell wall
Enzyme Classification2.4.1.227
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbableUPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG
CommentsML0914, len: 407 aa. Probable UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase (EC 2.4.1.-). Identical to the previously sequenced Mycobacterium leprae UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.-) SW:MURG_MYCLE (SW:O69552) (407 aa), Fasta scores: E(): 0, 99.8% identity in 407 aa overlap). Also highly similar to orthologues from Mycobacterium tuberculosis Rv2153c SW:MURG_MYCTU (SW:O06224) (410 aa), Fasta scores: E(): 0, 76.3% identity in 401 aa overlap and Escherichia coli SW:MURG_ECOLI (SW:P17443) (354 aa), Fasta scores: E(): 4.2e-21, 38.1% identity in 365 aa overlap. Contains a possible membrane spanning hydrophobic domain.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS10833041084527+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0914|murG
VNNSVREPTRGRRGSPPVADAALSVNPPLSVVLAGGGTAGHVEPAMAVADALRALDPQVRITALGTSRGLETRLVPERGYHLELITPVPLPRKLTGDLARLPLRVWRAVRETRAVFEVVEAHVVVGFGGYVALPAYLAARGIPRVRRRIPVVVHEANARAGIANRVGVRTAERVLSAVPGSGLRGAEVVGVPIHATITTLNRPALRADARKHFGFTDDARVLLVFGGSQGAVSLNRAVAGAAEDLAASGVAVLHAYGLKNTLELRTPEYGEPPYVAVPYLDRMDLAYAAADLVICRSGAMTVAEVSAVGLPAIYVPFPIGNGEQRLNALPVVNAGGGLVVADADLTPGLVARQVVRLFSDPAQLAAMTAAAARVGHRDAAHHVAKVALDLARAERDTASGRSAGGKP
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