Gene ML0915 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemurC
Gene length1488 bp
IdentifierML0915
Location 1084524 bp
Protein summary information
Molecular mass51556.0 Da
Isoelectric point6.88
Protein length496 amino acids
Structural information
PFAMPF01225, PF02875, PF08245
Orthologs
M. tuberculosis H37RvRv2152c
M. lepromatosis Mx1-22AMLPM_0915
Cross-references
UniProtP57994
Gene OntologyUdp-n-acetylmuramate-l-alanine ligase activity, Cell cycle, Cell division, GO:0007047, Cytoplasm, Peptidoglycan biosynthetic process, Regulation of cell shape, Atp binding
Enzyme Classification6.3.2.8
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable UDP-N-acetylmuramate-alanine ligase MurC
CommentsML0915, len: 495 aa. Probable murC, UDP-N-acetylmuramate-alanine ligase (EC 6.3.2.8). Identical, over available sequence, to the previously sequenced Mycobacterium leprae UDP-N-acetylmuramate-alanine ligase (fragment) TR:O69551 (EMBL:AL022602) (235 aa), Fasta scores: E(): 0, 99.6% identity in 235 aa overlap. Also highly similar to UDP-N-acetylmuramate-alanine ligases from Mycobacterium tuberculosis SW:MURC_MYCTU (SW:O06225) (494 aa), Fasta scores: E(): 0, 79.8% identity in 494 aa overlap and Escherichia coli SW:MURC_ECOLI (SW:P17952) (491 aa), Fasta scores: E(): 0, 35.2% identity in 477 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. Belongs to the murCDEF family.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS10845241086011+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0915|murC
VNAGQLPPELQRVHMVGIGGSGMSGIARILLDRGGLVSGSDAKESRVVHALRARGALIRIGHDASLLDLLPGGATAVITIRTAIPKTNPELVEARRRGIPVLLRSAVLARLMDGCTTLMVAGTHGKTTTTSMLVVALQHCGCDPSFVVGGELAVVGTNAHHGLGACFVAEADESDGSLLEYTPNVAVVTNIDSDHLDFYGSVDAYIRVFDSFVERFALGGALVVCNDDPGAAALARRTAELGIRVLRYGSDDRIGETLAARLLSWEQQGTGAVAHIQLAGQPNSRVMRLPVPGRHMALNALGALLAAIEIGASTDEVLDGLAGFRGVRRRFELVGTSGVGQASNSLVRVFDDYAHHPTEISATLAAFRIMLEQSGGGRCIVVFQPHLYSRTKALSREFGRALSAADEVFIVGVNGAREQPLAGVSGASVAKHVSVPVRYIPDYSAVVIEVAAAAGPGDVIVTMGIGDVGLLGPEIVAALRVRANCNTPGCSGVLQ
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