Gene ML0925 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameglnA
Gene length1437 bp
IdentifierML0925
Location 1094379 bp
Protein summary information
Molecular mass53545.9 Da
Isoelectric point4.89
Protein length479 amino acids
Structural information
PFAMPF00120, PF03951
Orthologs
M. tuberculosis H37RvRv2220
M. lepromatosis Mx1-22AMLPM_0925
Cross-references
UniProtQ9CCD8
Gene OntologyGlutamate-ammonia ligase activity, Glutamine biosynthetic process, Nitrogen fixation, Cytoplasm
Enzyme Classification6.3.1.2
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductGLUTAMINE SYNTHETASE GLNA1 (GLUTAMINE SYNTHASE) (Glutamate--ammonia ligase 1) (GS-I)
CommentsML0925, len: 478 aa. Probable glnA, glutamine synthase class I (EC 6.3.1.2). Highly similar to many glutamine synthetases (EC 6.3.1.2) including examples from: Mycobacterium tuberculosis Rv2220 SW:GLN1_MYCTU (Q10377) (478 aa), Fasta scores: E(): 0, (91.8% identity in 478 aa overlap) and Salmonella typhimurium SW:GLNA_SALTY (P06201) (468 aa), Fasta scores: E(): 0, (51.5% identity in 474 aa overlap). Also similar to ML1631 from M. leprae. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase. Contains PS00182 Glutamine synthetase class-I adenylation site. Contains PS00180 Glutamine synthetase signature 1. Contains PS00181 Glutamine synthetase putative ATP-binding region signature. Belongs to the glutamine synthetase family.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS10943791095815+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0925|glnA
VTEKTSDDVLKLAKDENIEFVDVQFCDLPGIMQHFTIPASAFDKSVFEDGLAFDGSSIRGFQSIHESDMLLFPDPDTARIDPFRAAKTLNVNFFVHDPFTLEPYSRDPRNIARKAENYLISTGIADTVYFGAEAEFYIFDSVSFDSRSNGSFYQVDAISGWWNTGAATESDGSPNRGYKVRHKGGYFPVAPNDQYVDLRDKMLTNLTNAGFVLEKGHHEVGTGGQGEINYQFNTLLHAADDMQLYKYIVKNTAWQNGKTVTFMPKPLFGDNGSGMHTHQSLWKGGTPLMYDEIGYAGLSDTARHYIGGLLHHAPSLLAFTNPTVNSYKRLVPGYEAPIKLVYSQRNRSACVRIPITGKNPKAKRLEFRCPDASGNPYLAFSAMLMAGLDGIKNKIEPQAPVDKDLYELPPEEAADIPQAPTQLAAVIDRLEEDHDYLTEGSVFTPDLIETWINFKRENEIEPVNIRPHPYEFALYYDV
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