Gene ML0955c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameppdK
Gene length1806 bp
IdentifierML0955c
Location 1123020 bp
Protein summary information
Molecular mass65293.5 Da
Isoelectric point5.48
Protein length602 amino acids
Structural information
PFAMPF00391, PF01326
Orthologs
M. tuberculosis H37RvRv1127c
M. lepromatosis Mx1-22AMLPM_0955
Cross-references
UniProtO05566
Gene OntologyKinase activity, Phosphorylation, Atp binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE PYRUVATE, PHOSPHATE DIKINASE PPDK
CommentsML0955c, len: 601 aa. Probable ppdK, pyruvate, phosphate dikinase (EC 2.7.9.1). Identical to the previously sequenced Mycobacterium leprae pyruvate, phosphate dikinase TR:O05566 (EMBL:Z94723) (601 aa), Fasta scores: E(): 0, 99.8% identity in 601 aa overlap. Also highly similar to pyruvate, phosphate dikinases from Mycobacterium tuberculosis Rv1127c TR:O06579 (EMBL:Z95585) (490 aa), Fasta scores: E(): 0, 71.8% identity in 478 aa overlap and Clostridium symbiosumSW:PODK_CLOSY (P22983) (873 aa), Fasta scores: E(): 0, 35.2% identity in 537 aa overlap. Contains Pfam match to entry PF00391 PEP-utilizers, PEP-utilizing enzymes. Contains Pfam match to entry PF01326 PPDK_N_term, Pyruvate phosphate dikinase, PEP/pyruvate binding domain.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS11230201124825-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML0955c|ppdK
LPGQSHKEPHRRATSTPRSLKQATSELRWALSLAAPESPAFMRHLLGNAHDKVDITTSSEHVAAFTEHAIVLLNGNAHQTRELLGGKGYNINAMRRHQLAVPPAFCITTEVGVRYLAAPTPTMEAIWNDVLDQMRWLEAETSRTFGWGPRPLLVSIRSGAVQSMPGMMDTILNLGINDPVEQALAAASPSPIPQTFARDTRLRFIRTYRRIVDPLNPPPANTYDQLRAAIESIFSSWNSPRAVAYRTHYGLDDQSGTAVIVQAMVFGNQGAYSGAGTLFSRNPITRESKLFGEWLPGGQGDDVVSGLVEVQPITSLRDEQPTVYDELVDTAGRLERLGSDVQEIEFTTEDSKLWLLQTRVAERSAQVAVRLALQLWQEGLIDDAEALRRVTPVHVETVLLPVLQPENHLSATLLAKGTPTCPGVISGKAYTEVDEALDAAESAEQVILVRDHTRPDDVLGMLASQGVVTEVGGAASHAAVVSRELSRVAVVGCGQGTAVSLAGKQITVDGDKGEVRQGNLTLSAWSENETPELRELADIARRISPLRVHMTEDHTRLDDSSDTAVRLAINTGHADVVSATPLIVMMTTLRLQDSKDSSAKS
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