Gene ML1013c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | TRANSCRIPTIONAL REGULATORY PROTEIN (REPRESSOR AND ACTIVATOR), IRON-BINDING REPRESSOR OF SIDEROPHORE BIOSYNTHESIS AND IRON UPTAKE. SEEMS TO REGULATE A VARIETY OF GENES ENCODING A VARIETY OF PROTEINS e.g. TRANSPORTERS, PROTEINS INVOLVED IN SIDEROPHORE SYNTHESIS AND IRON STORAGE, MEMBERS OF THE PE/PPE FAMILY, ENZYMES INVOLVED IN LIPID METABOLISM, TRANSCRIPTIONAL REGULATORY PROTEINS, ETC. ALSO ACTIVATOR OF BFRA GENE. |
| Product | IRON-DEPENDENT REPRESSOR AND ACTIVATOR IDER |
| Comments | ML1013c, len: 230 aa. Probable ideR, iron dependent repressor and activator. Highly similar to multiple iron-binding regulatory proteins such as Mycobacterium tuberculosis Rv2711 SW:IDER_MYCTU (Q50495) (230 aa), Fasta scores: E(): 0, 90.0% identity in 230 aa overlap and Corynebacterium diphtheriae SW:DTXR_CORDI (P33120) (226 aa), Fasta scores: E(): 0, 56.1% identity in 230 aa overlap. Contains Pfam match to entry PF01325 Fe_dep_repress, Iron dependent repressor. |
| Functional category | Regulatory proteins |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1183484 | 1184176 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1013c|ideR
MNDLVDTTEMYLRTIYDLEEEGVTPLRARIAERLEQSGPTVSQTVSRMERDGLLRVAGNRHLELTTKGRAMAIAVMRKHRLAERLLVDVIGLPWEEVHAEACRWEHVMSEDVERRLIKVLNNPTTSPFGNPIPGLLDLGAGPDASAANAKLVRLTELPSGSPVAVVVRQLTEHVQDDIDLITRLKDTGVVPNARVTVETSPAGNVIIIIPGHENVTLPHEMAHAVKVEKV
Bibliography
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