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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionTRANSCRIPTIONAL REGULATORY PROTEIN (REPRESSOR AND ACTIVATOR), IRON-BINDING REPRESSOR OF SIDEROPHORE BIOSYNTHESIS AND IRON UPTAKE. SEEMS TO REGULATE A VARIETY OF GENES ENCODING A VARIETY OF PROTEINS e.g. TRANSPORTERS, PROTEINS INVOLVED IN SIDEROPHORE SYNTHESIS AND IRON STORAGE, MEMBERS OF THE PE/PPE FAMILY, ENZYMES INVOLVED IN LIPID METABOLISM, TRANSCRIPTIONAL REGULATORY PROTEINS, ETC. ALSO ACTIVATOR OF BFRA GENE.
ProductIRON-DEPENDENT REPRESSOR AND ACTIVATOR IDER
CommentsML1013c, len: 230 aa. Probable ideR, iron dependent repressor and activator. Highly similar to multiple iron-binding regulatory proteins such as Mycobacterium tuberculosis Rv2711 SW:IDER_MYCTU (Q50495) (230 aa), Fasta scores: E(): 0, 90.0% identity in 230 aa overlap and Corynebacterium diphtheriae SW:DTXR_CORDI (P33120) (226 aa), Fasta scores: E(): 0, 56.1% identity in 230 aa overlap. Contains Pfam match to entry PF01325 Fe_dep_repress, Iron dependent repressor.
Functional categoryRegulatory proteins
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS11834841184176-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML1013c|ideR
MNDLVDTTEMYLRTIYDLEEEGVTPLRARIAERLEQSGPTVSQTVSRMERDGLLRVAGNRHLELTTKGRAMAIAVMRKHRLAERLLVDVIGLPWEEVHAEACRWEHVMSEDVERRLIKVLNNPTTSPFGNPIPGLLDLGAGPDASAANAKLVRLTELPSGSPVAVVVRQLTEHVQDDIDLITRLKDTGVVPNARVTVETSPAGNVIIIIPGHENVTLPHEMAHAVKVEKV
      
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