Gene ML1038
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN THE DEOXYXYLULOSE-5-PHOSPHATE PATHWAY (DXP) OF ISOPRENOIDBIOSYNTHESIS (AT THE FIRST STEP), AND IN THE BIOSYNTHETIC PATHWAY TO THIAMINE AND PYRIDOXOL (AT THE FIRST STEP). CATALYZES THE ACYLOIN CONDENSATION REACTION BETWEEN ATOMS 2 AND 3 OF PYRUVATE AND GLYCERALDEHYDE 3-PHOSPHATE TO YIELD 1-DEOXY-D-XYLULOSE-5-PHOSPHATE (DXP). |
| Product | PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS1 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS) |
| Comments | ML1038, len: 643 aa. Probable dxs1, 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.-.-). Identical to the previously sequenced Mycobacterium leprae probable 1-deoxyxylulose-5-phosphate synthase (DXP synthase) SW:DXS_MYCL (Q50000) (643 aa), Fasta scores: E(): 0, 100.0% identity in 643 aa overlap. Also highly similar to many members of the transketolase family including DXP synthases from Mycobacterium tuberculosis Rv2682c SW:DXS_MYCTU (O07184) (638 aa), Fasta scores: E(): 0, 86.4% identity in 632 aa overlap and Escherichia coli SW:DXS_ECOLI (P77488) (619 aa), Fasta scores: E(): 0, 39.2% identity in 625 aa overlap. Contains PS00801 Transketolase signature 1. Contains PS00802 Transketolase signature 2. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1201218 | 1203149 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1038|dxs
MLEQIRRPADLQHLSQQQLRDLAAEIRELLVHKVAATGGHLGPNLGVVELTLALHRVFDSPHDPIIFDTGHQAYVHKMLTGRCQDFDSLRKKAGLSGYPSRAESEHDWVESSHASTALSYADGLAKAFELAGNRNRHVVAVVGDGALTGGMCWEALNNIAATPRPVVIVVNDNGRSYAPTIGGVADHLATLRLQPAYERLLEKGRDALHSLPLIGQIAYRFMHSVKAGIKDSLSPQLLFTDLGLKYVGPVDGHDEHAVEVALRKARGFGGPVIVHVVTRKGMGYPPAEADQAEQMHTCGVMDPTTGQPTKIAAPDWTAIFSDALIGYAMKRRDIVAITAAMPGPTGLTAFGQCFPDRLFDVGIAEQHAMTSAAGLAMGRMHPVVAIYSTFLNRAFDQIMMDVALHKLPVTMVIDRAGITGSDGPSHNGMWDLSMLGIVPGMRVAAPRDAIRLREELGEALDVDDGPTAIRFPKGDVCEDIPALKRRSGVDVLAVPATGLAQDVLLVGVGVFASMALAVAKRLHNQGIGVTVIDPRWVLPVCDGVLELAHTHKLIVTLEDNGVNGGVGAAVSTALRQVEIDTPCRDVGLPQEFYDHASRSEVLADLGLTDQDVARRITGWVVAFGHCGSGDDAGQYGPRSSQTM
Bibliography
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