Gene ML1044
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) |
| Comments | ML1044, len: 451 aa. Probable hemY, protoporphyrinogen oxidase (EC 1.3.3.4). Identical to the previously sequenced Mycobacterium leprae protoporphyrinogen oxidase (EC 1.3.3.4) SW:PPOX_MYCLE (Q50008) (451 aa), Fasta scores: E(): 0, 100.0% identity in 451 aa overlap. Also highly similar to many others including: Mycobacterium tuberculosis Rv2677c SW:PPOX_MYCTU (O53230) (426 aa), Fasta scores: E(): 0, 75.8% identity in 429 aa overlap and Bacillus subtilis SW:PPOX_BACSU (P32397) (470 aa), Fasta scores: E(): 2.2e-13, 27.1% identity in 458 aa overlap. Contains Pfam match to entry PF01208 URO-D, Uroporphyrinogen decarboxylase (URO-D). BELONGS TO THE PROTOPORPHYRINOGEN OXIDASE FAMILY. COFACTOR: CONTAINS ONE FAD PER HOMODIMER. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1209290 | 1210645 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1044|hemY
MTSRSYCVVGGGISGLTAAYRLRVATGDDVAITLFDPGDRLGGVLRTECVGGQPMDLGAEAFLLRRPEVPALLAELGLSERQRATTDARPLIYSQQRLHSLPPDTVAGIPSSATSVAGLVDDATVARIGAEAVRPLSWEPGSDPAMAELVADRFGEQAVARLVDPLLGGVYAGSAATIGLRAGAPSVAAALDCGATSLMEAVRQGLPPVAAGPVFGALDGGYQVLIDELVRRSRLQWVAATVVGLDRGTCGWTLVDDTGACWSADGVILAVPAPRLVRLLQQIAPRTVAAASRIVSASSAVVALSVPRDTTFPQNSGVLVASGERLRAKAVTLSSRKWGLQGDTQLVRLSFGKFGDQVASTASDDELLAWAVSDLAAVFDVTVDPVDVCVQRWIDAMPQYGPGHADLVAEVRAGLPPTLVVAGSHMDGIGVPACISAAGRAIEALQAEVAR
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