Gene ML1051 (xclC) in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namefadD36
Gene length1431 bp
IdentifierML1051
Location 1217112 bp
Protein summary information
Molecular mass50098.2 Da
Isoelectric point5.79
Protein length477 amino acids
Structural information
PFAMPF00501
Orthologs
M. tuberculosis H37RvRv1193
M. lepromatosis Mx1-22AMLPM_1051
Cross-references
UniProtQ50017
Gene OntologyMetabolic process, Catalytic activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE FATTY-ACID-CoA LIGASE FADD36 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)
CommentsML1051, len: 476 aa. Probable fadD36, fatty-acid-CoA synthetase (EC 6.2.1.-). Identical to the previously sequenced Mycobacterium leprae XclC TR:Q50017 (EMBL:U15181) (476 aa), Fasta scores: E(): 0, 99.8% identity in 476 aa overlap. Also highly similar to many others including: Mycobacterium tuberculosis fatty-acid-CoA synthetase Rv1193 fadD36 TR:O05295 (EMBL:Z93777) (473 aa), Fasta scores: E(): 0, 81.3% identity in 476 aa overlap and Escherichia coli long-chain-fatty-acid--coa ligase (EC 6.2.1.3) SW:LCFA_ECOLI (P29212) (561 aa), Fasta scores: E(): 1.3e-28, 31.7% identity in 378 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. Contains PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. BELONGS TO THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Note previously known as xclC
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS12171121218542+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1051|fadD36
VLLASLNPSVVTATDIADAVCVDGVVLSRSGLVGAATSVAERVGGARLVAVLATPTASTVLAITGCLIAGVPVVPVPADIGVVERRHMLTDSGAQAWLGPGPSADSAPDGLPHIPVQLDARSWNRYPEPSPDATAMVIYTSGTTGPPKGVLLSRRAIAVDLDALAQAWQWTADDVLVHGLPLFHVHGLVLGLLGSLRIGNRFVHTGKPTPTAYAQACSEAGGSLYFGVPTVWSRLVADEAVARALRPARLLVSGSASLPVPVFDRLAHLTGHRPIERYGSTESLITLSTLADGERRAGWVGLPLAGVQTRLVDESGGPVPYDGETVGRLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTGDVAVVDSGGMHRIVGRESVDLIKLGGYRIGAGEIEMALLGHPDVREVAVVGLPDEDLGQRIVAFVVGAEALDADELINYVAQQLSIHKRPREVRFVDALPRNAMGKVLKKQLLFEG
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