Gene ML1075c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameML1075c
Gene length675 bp
IdentifierML1075c
Location 1238389 bp
Protein summary information
Molecular mass23221.2 Da
Isoelectric point4.54
Protein length225 amino acids
Structural information
PFAMPF01596
Orthologues
M. tuberculosisRv1220c
Cross-references
UniProtQ9CCA7
Gene OntologyO-methyltransferase activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE METHYLTRANSFERASE
CommentsML1075c, len: 224 aa. Probable methyltransferase (EC 2.1.1.-). Previously sequenced Mycobacterium leprae TR:Q49969 (EMBL:U15180) (136 aa), Fasta scores: E(): 0, 100.0% identity in 136 aa overlap. Also highly similar to Mycobacterium tuberculosis possible methyltransferase Rv1220c TR:O33219 (EMBL:Z98260) (215 aa), Fasta scores: E(): 0, 85.5% identity in 214 aa overlap and Streptomyces mycarofaciens O-methyltransferase (EC 2.1.1.-) involved in the synthesis of the macrolide antibiotic midecamycin SW:MDMC_STRMY (Q00719) (221 aa), Fasta scores: E(): 2.3e-11, 30.5% identity in 223 aa overlap. Contains Pfam match to entry PF01596 Methyltransf_3, O-methyltransferase.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS12383891239063-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1075c|ML1075c
MYGTGNNAVTPDQAAASRADSLFAHAEGSISEDAILASARERSEEIGARAVTPAVGALLSLLTKLSGGKAVAEVGTGAGVSGLWLLSGMSYDGVLTTIDIEPEYLRLAKQAFSEAGIGPSRTRLISGRGQDVLTRLADESYDLVFIDADPIDQPAYVVEGVRLLRSCGIIVVHRAALGGRAGDPAARDAEVTAVREAARLIAENERLTPALVPLGDGLLAAVRE
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