Go to browser
virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE SERINE PROTEASE HTRA (DEGP PROTEIN)
CommentsML1078, len: 533 aa. Probable htrA, serine protease (EC 3.4.21.-). Identical to the previously sequenced Mycobacterium leprae TR:Q49972 (EMBL:U15180) (533 aa), Fasta scores: E(): 0, 99.8% identity in 533 aa overlap. Also highly similar to Mycobacterium tuberculosis possible serine protease HtrA Rv1223 TR:O06291 (EMBL:Z98260) (528 aa), Fasta scores: E(): 0, 81.8% identity in 533 aa overlap. The C-terminus of this CDS is similar to several proven proteases e.g. Escherichia coli SW:HTRA_ECOLI (P09376) (474 aa), Fasta scores: E(): 2e-26, 35.3% identity in 283 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF). Contains Pfam match to entry PF00089 trypsin, Trypsin. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS12407751242376+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML1078|htrA
VNTRVDTDNAVIRYRRRNRPCLERSEEDNVTSDQGTNNDQNPGHHLATRPVARPPVDAASREAFGRPCGFSGSFVAEYVRPQKYRDRSEFRPDDQPADPVLAEAFSRPFGSVDSLQRHPIDAGALAAEKDATQLDEPDDPWRDPAAAATLASPAVASPVPHTELGQCGKLGVRDVLFGGRVSYLALVILVFIALALGAIGGVIGRKTAEIVDAFTTSKVTLATTNNTEEPAGRFAKVAAAVADSVVTIESKSDQEEMQGSGVIIDGRGYIVTNNHVISEAANKPSQFKTTVVFNDGKDVPANLVGRDPKTDLAVLKVDNVDNLTVARLGDSGKVRVGDEVIAAGAPLGLRSTVTHGIVSALHRPVPLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDMDSQVIGINTAGKSLSDSASGLSFAIPVDEMKSVVQTLIKDGKIVHPTLGVSTRSVSNAIASGAQVANVKAGSPAQKGGILENDVIVKVGNRKVADADEFIVAVRQLTIGQDASVEVVRDGRHVTLTVKSDPDSS
      
Bibliography
No article yet recorded