Gene ML1078
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE SERINE PROTEASE HTRA (DEGP PROTEIN) |
| Comments | ML1078, len: 533 aa. Probable htrA, serine protease (EC 3.4.21.-). Identical to the previously sequenced Mycobacterium leprae TR:Q49972 (EMBL:U15180) (533 aa), Fasta scores: E(): 0, 99.8% identity in 533 aa overlap. Also highly similar to Mycobacterium tuberculosis possible serine protease HtrA Rv1223 TR:O06291 (EMBL:Z98260) (528 aa), Fasta scores: E(): 0, 81.8% identity in 533 aa overlap. The C-terminus of this CDS is similar to several proven proteases e.g. Escherichia coli SW:HTRA_ECOLI (P09376) (474 aa), Fasta scores: E(): 2e-26, 35.3% identity in 283 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF). Contains Pfam match to entry PF00089 trypsin, Trypsin. Contains PS00017 ATP/GTP-binding site motif A (P-loop). |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1240775 | 1242376 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1078|htrA
VNTRVDTDNAVIRYRRRNRPCLERSEEDNVTSDQGTNNDQNPGHHLATRPVARPPVDAASREAFGRPCGFSGSFVAEYVRPQKYRDRSEFRPDDQPADPVLAEAFSRPFGSVDSLQRHPIDAGALAAEKDATQLDEPDDPWRDPAAAATLASPAVASPVPHTELGQCGKLGVRDVLFGGRVSYLALVILVFIALALGAIGGVIGRKTAEIVDAFTTSKVTLATTNNTEEPAGRFAKVAAAVADSVVTIESKSDQEEMQGSGVIIDGRGYIVTNNHVISEAANKPSQFKTTVVFNDGKDVPANLVGRDPKTDLAVLKVDNVDNLTVARLGDSGKVRVGDEVIAAGAPLGLRSTVTHGIVSALHRPVPLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDMDSQVIGINTAGKSLSDSASGLSFAIPVDEMKSVVQTLIKDGKIVHPTLGVSTRSVSNAIASGAQVANVKAGSPAQKGGILENDVIVKVGNRKVADADEFIVAVRQLTIGQDASVEVVRDGRHVTLTVKSDPDSS
Bibliography
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