Gene ML1095c (odhA)
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | THE 2-OXOGLUTARATE DEHYDROGENASE COMPLEX CATALYZES THE OVERALL CONVERSION OF 2-OXOGLUTARATE TO SUCCINYL-CoA & CO(2). IT CONTAINS MULTIPLE COPIES OF 3 ENZYMATIC COMPONENTS:2-OXOGLUTARATE DEHYDROGENASE (E1), DIHYDROLIPOAMIDE SUCCINYLTRANSFERASE (E2) AND LIPOAMIDE DEHYDROGENASE (E3) [CATALYTIC ACTIVITY: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2] |
| Product | PROBABLE 2-OXOGLUTARATE DEHYDROGENASE SUCA (Alpha-ketoglutarate dehydrogenase) |
| Comments | ML1095c, len: 1260 aa. Probable sucA, 2-oxoglutarate dehydrogenase (EC 1.2.4.2). This CDS appears to constitute the E1 components of the 2-oxoglutarate dehydrogenase complex. The predicted product of this CDS is similar to several 2-oxoglutarate dehydrogenase e.g. Mycobacterium tuberculosis Rv1248c TR:O50463 (EMBL:AL021006) (1214 aa), Fasta scores: E(): 0, 89.0% identity in 1224 aa overlap and Corynebacterium glutamicum TR:P96746 (EMBL:D84102) (1257 aa), Fasta scores: E(): 0, 58.9% identity in 1253 aa overlap. Contains Pfam match to entry PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases acyltransferase (catalytic domain). Contains Pfam match to entry PF00676 E1_dehydrog, Dehydrogenase E1 component. Previously known as odhA. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1260031 | 1263813 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1095c|sucA
VQKVASVAQCACRTEELRRTAAVANISSPFGQNEWLVEEMYRKFRDDPSSVDPSWHEFLVDYNPESTAEPVLTDPTSTDKQPSATPQAKPAAAADPVASRAKPATTPTVANGTAAGSAAAPAKTTTTPPIEGDELQVLRGAAAVVVKNMSASLDVPTATSVRAVPAKLMIDNRTVINNQLKRNRGGKISFTHLLGYALVQAVKKFPNINRHYAEIDGKPIAVTPAHTNLGLAIDLQGKDGKRSLVVAGIKRCEELRFAQFVTAYEDIVRRARDGKLTAEDFAGVTISLTNPGTIGTVHSVPRLMTGQGAIIGVGAMEYPAEFQGASAERIAELGIGKLITLTSTYDHRIIQGAESGDFLRTIHEMVLSDSFWDEIFRELSIPYLPVRWRTDNPDSIVDKNARVMELIAAYRNRGHLMADIDPLRLDNTRFRSHPDLDLLTHGLTLWDLDRVFKVNGFGGWKYKKLRDVLGLLRDAYCRHIGVEYTHILDPEQQEWLQQRVETKNVKPTVAEQKYILSKLNAAEAFETFLHTKYVGQKRFSLEGAESVIPMMDAAIDQCAKHGLDEVVIGMPHRGRLNVLANIVGKPYSQIFTEFEGNLNPTLAHSSGDVKYHLGATGLYLQMFGDNDIQVSLTANPSHLEAVDPVLEGLVRAKQDLLNKDTNGNQDEAFSVVPMMLHGDAAFAGQGVVAETLNLANLPGYRVGGTIHIIVNNQIGFTTAPEYSRSSEYCTDVAKMIGAPIFHVNGDDPEACVWVAKLAVDFRQRFKKDVVIDMLCYRRRGHNEGDDPSMTNPYMYDVVDTKRGARKSYTEALIGRGDISLKEAEDALRDYQGQLERVFNEVRDLEKHGVQPSESVESDQMIPAGLSTAVDKALLARIGDAFLAVPEGFTVHPRVQPVLEKRREMAYEGKIDWAFAELLALGSLVAEGKLVRLSGQDTKRGTFSQRHSVIIDRHTGEEFTPLQLLANNPDGSPTGGKFLVYNSPLSEYAAVGFEYGYTVGNPDAVVLWEAQFGDFVNGAQSIIDEFINSGEAKWGQLSTVVLLLPHGHEGQGPDHTSGRIERFLQLWAEGSMTFAVPSTPSNYFHLLRRHALDGIKRPLIVFTPKSMLRNKAAVSDIKDFTEIKFRSVLEEPTYEDSIDDRSKVTRVLLTCGKLYYELAARKIKDNRDDVAIVRIEQLAPLPRRRLGETLDRYENAKEFFWVQEEPANQGAWPRFGLELPELLPRLTGIKRISRRAMSAPSSGSSKVHAVEQQEILDTAFG
Bibliography
No article yet recorded
