Gene ML1114c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameML1114c
Gene length1755 bp
IdentifierML1114c
Location 1289626 bp
Protein summary information
Molecular mass63667.7 Da
Isoelectric point8.45
Protein length585 amino acids
Structural information
PFAMPF00005, PF00664
Orthologs
M. tuberculosis H37RvRv1273c
M. lepromatosis Mx1-22AMLPM_1114
Cross-references
UniProtQ9CC88
Gene OntologyTransport, Atp binding, Atpase activity, coupled to transmembrane movement of substances, Integral to membrane
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER
CommentsML1114c, len: 584 aa. Probable drugs-transport transmembrane ATP-binding protein ABC transporter. Highly similar to many proposed ABC transporter proteins including: Mycobacterium tuberculosis Rv1273c SW:YC73_MYCTU (Q11046) (582 aa), Fasta scores: E(): 0, 78.4% identity in 583 aa overlap and Bacillus subtilis hypothetical ABC transporter ATP-binding protein SW:YFIB_BACSU (P54718) (573 aa), Fasta scores: E(): 0, 34.4% identity in 569 aa overlap. Also similar to the adjoining CDS ML1113c. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00211 ABC transporters family signature.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS12896261291380-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1114c|ML1114c
MLLALLRQYIRPYRRLVAVLMVLQLVSTLASLYLPTINAAIIDDGVSKGNTAIIVRLGIVMLAVTGLQALCSVGAVYFGSRTGMSFGRDLRSAMFDHITTFSERETARFGAPTLLTRTTNDVRQIQYLVQISGTVLVTPPIMCIGGIVMAIYQEAALTWLLLVSVPILAVTNYWIISHMLPLFRSMQSLIDDINRVMRDQLAGIRVIRAFTRESFERNRFERANIALSNAALNAGNWQALMLPTTALTINVSSVALIWFGGLRIDSGQMQIGSLAAFLTYFTQILMAVLMATMALVVLPRASVCAQRITEVLSTRPAVGNPPCPHIPRGKVTGVVRLDGVTFTYPGTNHPALQDISFTALPGTTTAVVGSTGSGKSTLVALICRLYDVTAGAVLVDEVDVRNYNAERLWSVIGLVPQRCYLFSGTVADNLRYGATPGQVITDDQMWEALHMADAEEFIRAHNDGLHMRVAQGGINFSGGQRQRLAIARAIIRHPTIYLFDDAFSALDVHTDSRVSKSLREMFRDVTIIVVTQRISTAAQADQVIVVDDGKLAGSGTHESLLADCTIYAEFAYSQSFGGGVRDSQ
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