Gene ML1128
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE DIAMINOPIMELATE DECARBOXYLASE LYSA (DAP DECARBOXYLASE) |
| Comments | ML1128, len: 472 aa. Probable lysA, diaminopimelate decarboxylase (EC 4.1.1.20). Previously sequenced Mycobacterium leprae Q50140|U15186 (495 aa), Fasta scores: E(): 0, 100.0% identity in 472 aa overlap. Highly similar to many diaminopimelate decarboxylases (EC 4.1.1.20) involved in the last step of lysine biosynthesis e.g. DCDA_MYCTU|P31848 Rv1293 LysA from Mycobacterium tuberculosis (447 aa), Fasta scores: E(): 0, (86.8% identity in 446 aa overlap). Also similar to ML0251c a possible pseudogene similar to M. tuberculosis lysA. Contains Pfam match to entry PF00750 tRNA-synt_1d, tRNA synthetases class I (R). Contains Pfam match to entry PF00278 Orn_DAP_Arg_deC, Pyridoxal-dependent decarboxylase. Contains PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1318223 | 1319641 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1128|lysA
VNVHTAGPRHAEKTRHTATPQRVQPSDDLLRLASNVWPRNITRDETGVACIAGNKLTDLAGEYGTPLFVIDEDDFRFRCREIAAAFGGGENVHYAAKAFLCTEIARWIDEEGLSLDVCSGGELAVALHASFPPERISLHGNNKSVAELKDAVKAGVGYIVLDSTTEIERLDAIAGEAGIVQDVLVRLTVGVEAHTHEFIATAHEDQKFGLSVASGAAMAAVRRVFATDNLRLVGLHSHIGSQIFDVAGFELAAHRVIGLLCDIVGEFDPEKTAQLSIVDLGGGLGISYLPDDDPPPIFELAAKLGAIVSNESAAVGLPVPKLMVEPGRAIAGPGTITLYEVGTIKDVDVSATAHRRYVSIDGGMSDNIRTALYDAQYDVRLVSRTSDAPAAPASIVGKHCESGDIVVRDTWVPDDLKPGDLVGVAATGAYCYSLSSRYNMLGRPAVVAVCAGQARLILRRETVDDLLSLEVR
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