Gene ML1129 (hom)
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN THE CONVERSION OF L-ASPARTATE TO HOMOSERINE (THIRD STEP). HOMOSERINE PARTICIPATES IN THE BIOSYNTHESIS OF THREONINE AND THEN ISOLEUCINE AND IN THE BIOSYNTHESIS OF METHIONINE [CATALYTIC ACTIVITY : L-HOMOSERINE + NAD(P)(+) = L-ASPARTATE 4-SEMIALDEHYDE + NAD(P)H.] |
| Product | PROBABLE HOMOSERINE DEHYDROGENASE THRA |
| Comments | ML1129, len: 441 aa. Probable thrA (hom), homoserine dehydrogenase (EC 1.1.1.3). Identical to the previously sequenced Mycobacterium leprae homoserine dehydrogenase SW:DHOM_MYCLE (P46806) (441 aa), Fasta scores: E(): 0, 99.8% identity in 441 aa overlap. Also highly similar to orthologues from Mycobacterium tuberculosis SW:DHOM_MYCTU (Q10601) (441 aa), Fasta scores: E(): 0, 89.5% identity in 438 aa overlap and Corynebacterium glutamicum SW:DHOM_CORGL (P08499) (445 aa), Fasta scores: E(): 0, 60.3% identity in 431 aa overlap. Contains Pfam match to entry PF00742 Homoserine_dh, Homoserine dehydrogenase. Contains Pfam match to entry PF01842 ACT, ACT domain. Contains PS01042 Homoserine dehydrogenase signature. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1319645 | 1320970 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1129|thrA
VFSDERTVGVAVLGLGNVGSEVVRIIEGSADDLAARIGAPLMLRGIGVRRVAVDRGVPVDLLTDNIEELVSRADVDIVVEVMGPVELSRKAILSALEHGKSVVTANKALLAASTGELAQAAESAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGTTNYILSAMDSTGADYDSALAGARALGYAEADPTADVEGHDAAAKAAILASIAFHTRVTADDVYREGITKITPADFVSARALGCTIKLLFICERITAADGQQRVSARVYPALVPMSHPLATVSGAFNAVVVEAEAAGRLMFYGQGAGGAPTASAVTGDLVMAARNRVLGSRGPKESKYAQLPMETIGFISTRYYVSMNVADKPGVLSGVAAEFAKREVSIAEVRQEGVVDDGGRRVGARIVVVTHGATDAALSETVDALADLDVVQGVTSVLRLEGISL
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