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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionINVOLVED IN THE CONVERSION OF L-ASPARTATE TO HOMOSERINE (THIRD STEP). HOMOSERINE PARTICIPATES IN THE BIOSYNTHESIS OF THREONINE AND THEN ISOLEUCINE AND IN THE BIOSYNTHESIS OF METHIONINE [CATALYTIC ACTIVITY : L-HOMOSERINE + NAD(P)(+) = L-ASPARTATE 4-SEMIALDEHYDE + NAD(P)H.]
ProductPROBABLE HOMOSERINE DEHYDROGENASE THRA
CommentsML1129, len: 441 aa. Probable thrA (hom), homoserine dehydrogenase (EC 1.1.1.3). Identical to the previously sequenced Mycobacterium leprae homoserine dehydrogenase SW:DHOM_MYCLE (P46806) (441 aa), Fasta scores: E(): 0, 99.8% identity in 441 aa overlap. Also highly similar to orthologues from Mycobacterium tuberculosis SW:DHOM_MYCTU (Q10601) (441 aa), Fasta scores: E(): 0, 89.5% identity in 438 aa overlap and Corynebacterium glutamicum SW:DHOM_CORGL (P08499) (445 aa), Fasta scores: E(): 0, 60.3% identity in 431 aa overlap. Contains Pfam match to entry PF00742 Homoserine_dh, Homoserine dehydrogenase. Contains Pfam match to entry PF01842 ACT, ACT domain. Contains PS01042 Homoserine dehydrogenase signature.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS13196451320970+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML1129|thrA
VFSDERTVGVAVLGLGNVGSEVVRIIEGSADDLAARIGAPLMLRGIGVRRVAVDRGVPVDLLTDNIEELVSRADVDIVVEVMGPVELSRKAILSALEHGKSVVTANKALLAASTGELAQAAESAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGTTNYILSAMDSTGADYDSALAGARALGYAEADPTADVEGHDAAAKAAILASIAFHTRVTADDVYREGITKITPADFVSARALGCTIKLLFICERITAADGQQRVSARVYPALVPMSHPLATVSGAFNAVVVEAEAAGRLMFYGQGAGGAPTASAVTGDLVMAARNRVLGSRGPKESKYAQLPMETIGFISTRYYVSMNVADKPGVLSGVAAEFAKREVSIAEVRQEGVVDDGGRRVGARIVVVTHGATDAALSETVDALADLDVVQGVTSVLRLEGISL
      
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