Gene ML1135 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namehemK
Gene length867 bp
IdentifierML1135
Location 1326904 bp
Protein summary information
Molecular mass31225.3 Da
Isoelectric point4.93
Protein length289 amino acids
Structural information
PFAMPF08241
Orthologs
M. tuberculosis H37RvRv1300
M. lepromatosis Mx1-22AMLPM_1135
Cross-references
UniProtP45832
Gene OntologyProtein methyltransferase activity, Protein methylation
Enzyme Classification2.1.1.-
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE PROTOPORHYRINOGEN OXIDASE HEMK HOMOLOG
CommentsML1135, len: 288 aa. Probable hemK, protoporphyrinogen oxidase. Highly similar to numerous members of the HemK family of modification methylases such as Mycobacterium tuberculosis, Rv1300, SW:HEMK_MYCTU (Q10602) (325 aa), Fasta scores: E(): 0, 73.9% identity in 284 aa overlap and Escherichia coli SW:HEMK_ECOLI (P37186) (277 aa), Fasta scores: E(): 2.4e-17, 32.5% identity in 277 aa overlap.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS13269041327770+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1135|hemK
MMIRLRRAIDSAVTQLEEAGIGSARCDAEQLAAHLAGTDRGRLALLDTPGEEFFRRYSDAVAARSRRVPLQHLIGTVSFGPVVLHVGPDVFIPRPETEAILAWVMAQRLPERPVIVDACTGSGALAVALAHHRPAARVIGIDDSDSALDYARRNAEGTAVECVRADVTTPALLPELDGCVDLFVANPPYVPDDPVVQSILEPEVTQYDPRHAVFGGPDGMALTADIVGLAGRWLRPGGLFAVEHDDSTSVPTLDLVYRTDLFDDVLTHRDLAGRPRFVTARRRESWSA
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