Gene ML1137 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namerfe
Gene length1200 bp
IdentifierML1137
Location 1328503 bp
Protein summary information
Molecular mass42169.9 Da
Isoelectric point9.53
Protein length400 amino acids
Structural information
PFAMPF00953
Orthologs
M. tuberculosis H37RvRv1302
M. lepromatosis Mx1-22AMLPM_1137
Cross-references
UniProtP45830
Gene OntologyLipopolysaccharide biosynthetic process, Magnesium ion binding, Manganese ion binding, Phospho-n-acetylmuramoyl-pentapeptide-transferase activity, Plasma membrane, Transferase activity, transferring glycosyl groups, Integral to membrane
Enzyme Classification2.7.8.-
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE UNDECAPAPRENYL-PHOSPHATE ALPHA-N-ACETYLGLUCOSAMINYLTRANSFERASE RFE (UDP-GlcNAc TRANSFERASE)
CommentsML1137, len: 399 aa. Probable rfe, undecaprenyl-phosphatealpha-N-acetylglucosaminyltransferase (EC 2.4.1.-). Previously sequenced Mycobacterium leprae SW:RFE_MYCLE (P45830) (398 aa), Fasta scores: E(): 0, 99.7% identity in 398 aa overlap. Similar to many including: Mycobacterium tuberculosis putative undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase SW:RFE_MYCTU (Q10606) (404 aa), Fasta scores: E(): 0, 89.2% identity in 398 aa overlap and Bacillus subtilis phospho-N-acetylmuramoyl-pentapeptide-transferase SW:MRAY_BACSU (Q03521) (324 aa), Fasta scores: E(): 1.9e-07, 28.6% identity in 297 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00953 Glycos_transf_4, Glycosyl transferase.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS13285031329702+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1137|rfe
LVQYVREMSSDLATFASGLLALFERSAGVPLRELALVGLTAAIITYFATGLVGVLANRLEAVAYPRERDVHVTPTPRMGGLAMYLGVLAAVFLASQLPALTRGFVYSSGMPAVLVAGAVITGIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYIPLGGVGTIVLDQTSSILLTLALTVSIVNAINFVDGLDGLAAGLGLITAMAICIFSVGLLRDHDGDVLFYPPAVISVVLAGSCLGFLPHNFHRAKIFMGDSGSMLVGLMLAAASTTAAGPISQNAYGTRDVFALLSPFLLVVAVMFVPMLDLLLAIVRRIRAGRSAFSPDKMHLHHRLLQIGHSHRRVVLLIYLWVGIVAFGAASTIFFNPRNTGAVMLGAIVITGMATVIPLLRRRDNY
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