Gene ML1142 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameatpH
Gene length1341 bp
IdentifierML1142
Location 1332059 bp
Protein summary information
Molecular mass48939.0 Da
Isoelectric point4.81
Protein length447 amino acids
Structural information
PFAMPF00213, PF00430
Orthologs
M. tuberculosis H37RvRv1307
M. lepromatosis Mx1-22AMLPM_1142
Cross-references
UniProtP53006
Gene OntologyProton-transporting atp synthase activity, rotational mechanism, Integral to membrane, Plasma membrane, Proton-transporting atp synthase complex, catalytic core f(1), Proton-transporting atp synthase complex, coupling factor f(o), Proton-transporting atpase activity, rotational mechanism, Atp synthesis coupled proton transport
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE ATP SYNTHASE DELTA CHAIN ATPH
CommentsML1142, len: 446 aa. Probable atpH, ATP synthase delta chain (EC 3.6.3.14). Previously sequenced Mycobacterium leprae SW:ATPD_MYCLE (P53006) (446 aa), Fasta scores: E(): 0, 100.0% identity in 446 aa overlap. The N-terminus of this protein shares high sequence identity with many ATP synthase B chain proteins e.g. Haemophilus influenzae SW:ATPF_HAEIN (P43720) (156 aa), Fasta scores: E(): 4.8e-05, 24.8% identity in 153 aa overlap and the C-terminus shares high homology with many ATP synthase [delta] chain proteins e.g. Streptomyces lividans SW:ATPD_STRLI (P50008) (272 aa), Fasta scores: E(): 3.4e-20, 33.1% identity in 266 aa overlap_ATP. Also highly similar over the entire range to Mycobacterium tuberculosis Rv1307 SW:ATPD_MYCTU (Q10594) (446 aa), Fasta scores: E(): 0, 77.8% identity in 446 aa overlap. Contains possible coiled-coils and a possible N-terminal signal sequence. Contains Pfam match to entry PF00213 OSCP, ATP synthase delta (OSCP) subunit. Contains Pfam match to entry PF00430 ATP-synt_B, ATP synthase B/B' CF(0). Contains PS01094 Uncharacterized protein family UPF0076 signature.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS13320591333399+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1142|atpH
MSTFIGQLVGFAAIVYLVWWYVVPPVCRLMRARRDAVRQQLTEAAEAADRLVEASQAHTKATEDAKVEAQRVVKEAVEDAKRIVEQLQAQADVEAERIKLQGARQVELLRAQLTRQLRLKFGHESVRQAAELVRNHVADAVQQSATVDRFLDDLDAMTPKGADVEYPLLAKMRSASRRALVDLADRFGAIAKSLDNQALYTLAGELVSVAKMLDREIVVTRYLTVPVEDEAPRVKLIDRLVSAHVGDPTMEILRAAVSERWSANTDLVDALEHISRQALLEVAEREDQIDEVEDQVFRFSRILDVAPRLAILLDDYAVPADSRVRLLCNVLQSASSVVNPIAVALLSQTVELLRGQPAKEAILFLAEVAVARRGEVVAQVSAAAEISDAQRTRLTEVLSRIYGHPVTVQMQIDAALLGGLSIVVGDEVIDGTLSSCLVAAEAALPD
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