Gene ML1143 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameatpA
Gene length1677 bp
IdentifierML1143
Location 1333461 bp
Protein summary information
Molecular mass60434.4 Da
Isoelectric point4.95
Protein length559 amino acids
Structural information
PFAMPF00006, PF00306, PF02874
Orthologs
M. tuberculosis H37RvRv1308
M. lepromatosis Mx1-22AMLPM_1143
Cross-references
UniProtP45825
Gene OntologyProton-transporting atp synthase activity, rotational mechanism, Plasma membrane, Plasma membrane atp synthesis coupled proton transport, Proton-transporting atp synthase complex, catalytic core f(1), Proton-transporting atpase activity, rotational mechanism, Atp binding
Enzyme Classification3.6.3.14
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE ATP SYNTHASE ALPHA CHAIN ATPA
CommentsML1143, len: 558 aa. Probable atpA, ATP synthase [alpha] chain (EC 3.6.3.14). Identical to the previously sequenced Mycobacterium leprae ATP synthase alpha chain (EC 3.6.1.34) SW:ATPA_MYCLE (P45825) (558 aa), Fasta scores: E(): 0, 100.0% identity in 558 aa overlap. Also highly similar to many other proposed ATPase alpha chain family proteins e.g. Mycobacterium tuberculosis Rv1308 TR:ATPA_MYCTU and Streptomyces lividans SW:ATPA_STRLI (P50001) (528 aa), Fasta scores: E(): 0, 69.0% identity in 516 aa overlap. Contains Pfam match to entry PF00006 ATP-synt_ab, ATP synthase alpha/beta family. Contains Pfam match to entry PF00422 ATP-synt_A-c, ATP synthase Alpha chain, C terminal. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00152 ATP synthase alpha and beta subunits signature.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS13334611335137+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1143|atpA
MAELTISADDIQNAIEEYVSSFTADTFREEVGTVVDVGDSIAHVEGLPSVMTQELLEFPGGILGVALNLDEHNVGAVILGDFENIKEGQKVKRTGDVLSVPVGEAFMGRVVNPLGQPIDGRGDIEAEARRALELQAPSVVQRQSVKEPLQTGIKAIDAMTPIGRGQRQLVIGDRKTGKTAVCVDTILNQRQNWESGDPKRQVRCVYVAIGQKGTTIASVRRALEEGGAMDYTTIVAALASDSAGFKWLAPYTGSAIAQHWMYDGKHVLIVFDDLTKQAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERCAKLADHLGGGSLTGLPIIETKANDISAYIPTNVISITDGQCFLETDLFNQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQYRELEAFAAFASDLDATSKAQLERGARLVELLKQPQYQPMPVEEQVISLFLGTGGHLDSVPVGDVRRFETELLDHIRVAQEEILTEIRESQKLTDEAADSLTEVIKSFKKGFAATGGASVVPNEHVAALDEEKLDKESVKVHQAIPAKTSEKSKNSTPR
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