Gene ML1145 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameatpD
Gene length1458 bp
IdentifierML1145
Location 1336078 bp
Protein summary information
Molecular mass53034.1 Da
Isoelectric point4.72
Protein length486 amino acids
Structural information
PFAMPF00006, PF00306, PF02874
Orthologs
M. tuberculosis H37RvRv1310
M. lepromatosis Mx1-22AMLPM_1145
Cross-references
UniProtP45823
Gene OntologyProton-transporting atp synthase activity, rotational mechanism, Hydrogen-exporting atpase activity, phosphorylative mechanism, Plasma membrane, Plasma membrane atp synthesis coupled proton transport, Proton-transporting atp synthase complex, catalytic core f(1), Proton-transporting atpase activity, rotational mechanism, Atp binding
Enzyme Classification3.6.3.14
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE ATP SYNTHASE BETA CHAIN ATPD
CommentsML1145, len: 485 aa. Probable atpD, ATP synthase [beta] chain (EC 3.6.3.14). Identical to the previously sequenced Mycobacterium leprae ATP synthase beta chain (EC 3.6.1.34) SW:ATPB_MYCLE (P45823) (485 aa), Fasta scores: E(): 0, 100.0% identity in 485 aa overlap. Also highly similar to many other proposed ATPase beta chain family proteins e.g. Mycobacterium tuberculosis Rv1310 SW:ATPB_MYCTU (Q10593) (486 aa), Fasta scores: E(): 0, 92.6% identity in 484 aa overlap and Streptomyces lividan SW:ATPB_STRLI (P50004) (477 aa), Fasta scores: E(): 0, 70.3% identity in 478 aa overlap. Contains Pfam match to entry PF00006 ATP-synt_ab, ATP synthase alpha/beta family. Contains Pfam match to entry PF00306 ATP-synt_ab_C, ATP synthase ab C terminal. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00152 ATP synthase alpha and beta subunits signature.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS13360781337535+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1145|atpD
MSTTKTTKMTVKTGSKGTSGRVVRVTGPVVDVEFPHGFVPELFNALNAKTTFSSLAKTLTLEVAQHLGDNLVRTISLQPTDGLVRGVEVTDTGNSISVPVGEGVKGHVFNALGYCLDEPGYGDEFEHWSIHRKPPSFEELEPRTEMLETGLKVVDLLTPYVRGGKIALFGGAGVGKTVLIQEMINRIARNFGGTSVFAGVGERTREGNDLWVELQEVNVLKDTALVFGQMDEPPGTRMRVALSALTMAEWFRDEASQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPTLADEMGELQERITSTRGRSITSMQAVYVPADDYTDPAPATTFAHLDATTELSRSVFAKGIFPAVDPLASSSTILDPGIVGEEHYRVAQEVIRILQRYKDLQDIIAILGIDELSEEDKQLVNRARRIERFLSQNMMAAEQFTGQPGSTVPVKETIDAFDRLCKGEFDHVPEQAFFLIGGLDDLTKKAESLGAKL
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