Gene ML1150 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemurA
Gene length1257 bp
IdentifierML1150
Location 1339583 bp
Protein summary information
Molecular mass44194.5 Da
Isoelectric point4.85
Protein length419 amino acids
Structural information
PFAMPF00275
Orthologs
M. tuberculosis H37RvRv1315
M. lepromatosis Mx1-22AMLPM_1150
Cross-references
UniProtP45821
Gene OntologyUdp-n-acetylglucosamine 1-carboxyvinyltransferase activity, Cell cycle, Cell division, GO:0007047, Cytoplasm, Peptidoglycan biosynthetic process, Regulation of cell shape, Udp-n-acetylgalactosamine biosynthetic process
Enzyme Classification2.5.1.7
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA
CommentsML1150, len: 418 aa. Probable murA, UDP-N-acetylglucosamine-1-carboxyvinyltransferase (EC 2.5.1.7). Identical to the previously sequenced Mycobacterium leprae UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) SW:MURA_MYCLE (P45821) (418 aa), Fasta scores: E(): 0, 99.8% identity in 418 aa overlap representing the first step in peptidoglycan biosynthesis. Also highly similar to many other UDP-N-acetylglucosamine 1-carboxyvinyltransferases e.g. Mycobacterium tuberculosis Rv1315 SW:MURA_MYCTU (Q10604) (418 aa), Fasta scores: E(): 0, 95.9% identity in 417 aa overlap and Escherichia coli SW:MURA_ECOLI (P2890) (419 aa), Fasta scores: E(): 0, 45.7% identity in 416 aa overlap. Contains Pfam match to entry PF00275 EPSP_syntase, EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase).
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS13395831340839+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1150|murA
VAERFVVTGGNRLSGEVTVGGAKNSVLKLMAATLLAEGTSTITNCPDILDVPLMAEVLRGLGATVELYGDVARITSPDEPKYDADFAAVRQFRASVCVLGPLVGRCKQARVALPGGDAIGSRPLDMHQAGLRQLGARCNIEHGCVVASAETLRGAEIQLEFPSVGATENILMAAVVAEGVTTIHNAAREPDVVDLCTMLNQMGAQVEGVGSPTMTITGVPRLYPTEHRVIGDRIVAATWGIAAAMTRGDIAVTGVDPAHLQLVLHKLHDAGATVTQTDDSFRVAQYERPKAVNVATLPFPGFPTDLQPMAIALTSIADGTSMITENVFEARFRFVEEMIRLGADARTDGHHAVVRGLPQLSSAPVWCSDIRAGAGLVLAGLVADGDTEVYDVFHIDRGYPLFVENLANLGAEIERVCL
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